帕罗西汀联合唑吡坦治疗原发性失眠的临床疗效与安全性

发布时间：2018-05-31 17:00

本文选题：帕罗西汀 + 唑吡坦　；参考：《中国临床药理学杂志》2016年09期

【摘要】：目的观察帕罗西汀联合唑吡坦与单用唑吡坦治疗原发性失眠的临床疗效与安全性。方法 57例原发性失眠患者随机分为试验组29例和对照组28例。试验组口服帕罗西汀10~20 mg·d~(-1),唑吡坦5~10 mg·d~(-1);对照组口服唑吡坦5~10 mg·d~(-1),2组疗程均为8周。治疗前后分别用多导睡眠图和匹兹堡睡眠质量指数量表评价2组的临床疗效;用不良反应症状量表(TESS)评估安全性。结果治疗后,试验组入睡时间、觉醒时间、睡眠时间分别为(29.60±4.80),(81.65±33.11),(388.75±32.81)min,显著优于对照组的(35.00±3.91),(121.29±32.48),(339.51±35.26)min(P0.05)。试验组的睡眠效率为(82.67±6.88)%,显著优于对照组的(73.69±7.01)%(P0.05)。试验组匹兹堡睡眠质量指数总分为(6.07±2.05),显著低于对照组的(8.57±2.47)(P0.05)。试验组不良反应发生率为27.59%,显著高于对照组的7.14%(P0.05)。结论帕罗西汀联合唑吡坦治疗原发性失眠患者疗效更优,且安全性高。
[Abstract]:Objective to observe the efficacy and safety of paroxetine combined with zolpidem and zolpidem alone in the treatment of primary insomnia. Methods 57 patients with primary insomnia were randomly divided into trial group (n = 29) and control group (n = 28). The experimental group was treated with paroxetine 1020 mg / d, zolpidem 10 mg / d ~ (-1) with zolpidem 10 mg / d and the control group with zolpidem 10 mg / d ~ (-1) for 8 weeks. The clinical efficacy of the two groups was evaluated by polysomnography and Pittsburgh Sleep quality Index scale before and after treatment, and the safety was evaluated with the adverse reaction symptom scale (TESS). Results after treatment, the sleep time, awakening time and sleep time in the experimental group were 29.60 卤4.80 and 388.75 卤32.81 min, respectively, which were significantly higher than those in the control group (121.29 卤32.48 min, 339.51 卤35.26 min, P 0.05). The sleep efficiency of the experimental group was 82.67 卤6.88, which was significantly better than that of the control group (73.69 卤7.01). The total score of Pittsburgh sleep quality index in the trial group was 6.07 卤2.05, which was significantly lower than that in the control group (8.57 卤2.47). The incidence of adverse reactions in the trial group was 27.59, which was significantly higher than that in the control group (7.14%, P 0.05). Conclusion Paroxetine combined with zolpidem is more effective and safe in the treatment of primary insomnia.
【作者单位】：杭州市第七人民医院医学心理科;杭州市第七人民医院科教科;
【基金】：浙江省自然科学基金资助项目(LQ13H090003) 杭州市重点专科专病基金资助项目(20140733Q44)
【分类号】：R740

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