残余胆固醇在急性冠脉综合征患者评估中的应用

发布时间：2018-06-02 21:02

本文选题：残余胆固醇 + 急性冠脉综合征　；参考：《上海交通大学学报(医学版)》2016年12期

【摘要】：目的·研究残余胆固醇(RC)水平对急性冠脉综合征(ACS)患者的临床应用评估。方法·利用生化法检测293例稳定型心绞痛患者、115例非高血压的ACS患者、72例合并高血压的ACS患者、91例疾病对照组患者和152例表观健康人群的总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-Ch)和低密度脂蛋白胆固醇(LDL-Ch)水平。RC由TC减去HDL-Ch和LDL-Ch得到,非高密度脂蛋白胆固醇(non-HDL-Ch)由TC减去HDL-Ch得到。对RC与TC、LDL-Ch、HDL-Ch、non-HDL-Ch的相关性进行分析。利用ROC曲线分析RC、LDL-Ch、non-HDL-Ch在鉴别稳定型心绞痛组和ACS中的作用。结果·ACS组、ACS合并高血压组的RC均显著高于稳定型心绞痛组(P0.05)。RC与TC、LDL-Ch、HDL-Ch和non-HDL-Ch相关性均有统计学意义(均P0.01)。稳定型心绞痛及ACS患者的ROC曲线分析表明,RC对于鉴别该2种疾病最佳,以下依次为non-HDL-Ch、LDL-Ch、TC、HDL-Ch。结论·RC水平在缺血性心脏病患者中明显升高,可作为ACS与稳定型心绞痛的鉴别指标。
[Abstract]:Objective to evaluate the clinical application of residual cholesterol in patients with acute coronary syndrome (ACS). Methods Total cholesterol (TC) and high density egg were detected by biochemical method in 293 patients with stable angina pectoris and 115 patients with ACS without hypertension. 72 patients with ACS complicated with hypertension and 91 patients with disease control group and 152 patients with apparent healthy people were studied. The levels of HDL-Chand LDL-ChC were obtained from TC minus HDL-Ch and LDL-Ch. Non high density lipoprotein cholesterol (non-HDL-Cho) was obtained from TC minus HDL-Ch. The correlation between RC and TCU LDL-Cho HDL-Cho non-HDL-Ch was analyzed. The role of non-HDL-Ch in distinguishing stable angina pectoris from ACS was analyzed by ROC curve. Results the RC of ACS group with hypertension was significantly higher than that of stable angina pectoris group (P 0.05). The correlation between RC and HDL-Ch and non-HDL-Ch were statistically significant (all P 0.01). The ROC curve analysis of patients with stable angina pectoris and ACS showed that RC was the best in differentiating the two diseases. Conclusion RC level is significantly higher in patients with ischemic heart disease and can be used as a differential index between ACS and stable angina pectoris.
【作者单位】：上海交通大学医学院附属新华医院检验科;
【基金】：上海市科委生物医药领域产学研医合作项目(14DZ1940200,14DZ1940203)~~
【分类号】：R541.4;R446.1

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