神经介入治疗患者颅内感染病原菌分布与耐药性分析

发布时间：2018-06-05 02:41

  本文选题：颅内感染 + 病原菌分布　； 参考：《中华医院感染学杂志》2016年20期

【摘要】：目的对神经介入治疗患者颅内感染病原菌的分布及药敏性进行分析,为临床治疗提供参考依据。方法选取医院2010年8月-2015年10月行神经介入治疗患者845例,脊髓穿刺法获取脑脊液标本,采用法国生物梅里埃公司VITEK-2Compact仪器进行菌种鉴定,并进行耐药性分析。结果 845例患者中分离出病原菌276株,其中革兰阴性菌138株占50.00%,革兰阳性菌86株占31.16%,真菌52株占18.84%;鲍氏不动杆菌、铜绿假单胞菌及肺炎克雷伯菌对氨苄西林、青霉素耐药率100.00%,肺炎克雷伯菌对亚胺培南、美罗培南的耐药率为10.71%、7.14%;金黄色葡萄球菌及表皮葡萄球菌对青霉素、头孢西丁的耐药率为100.00%;新型隐球菌对伏立康唑、氟康唑、两性霉素B敏感。结论神经内科介入治疗患者颅内感染以革兰阴性菌为主要病原菌,对多种抗感染类药物耐药性较高。
[Abstract]:Objective to analyze the distribution and drug sensitivity of pathogenic bacteria in patients with intracranial infection after nerve interventional therapy, and to provide reference for clinical treatment. Methods from August 2010 to October 2015, 845 patients were treated with interventional nerve therapy. Cerebrospinal fluid (CSF) samples were obtained by spinal cord puncture. The bacteria were identified by VITEK-2Compact instrument of French Bio-Meridier Company, and drug resistance was analyzed. Results 276 strains of pathogenic bacteria were isolated from 845 patients, of which 138 were Gram-negative bacteria, 86 Gram-positive bacteria accounted for 31.16 and 52 fungi accounted for 18.840.Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae were used to treat ampicillin. The resistance rate of Klebsiella pneumoniae to imipenem and meropenem was 10.71and 7.14; the resistance rate of Staphylococcus aureus and Staphylococcus epidermidis to penicillin and cefoxitin was 100.000.The resistance rate of Cryptococcus neoformans to Volconazole and fluconazole was 100.00.The resistance rate of Klebsiella pneumoniae to imipenem and meropenem was 10.71and 7.14. Amphotericin B is sensitive. Conclusion Gram-negative bacteria are the main pathogens in patients with intracranial infection after interventional therapy in neurology department.
【作者单位】： 青岛市第三人民医院神经内科;上海华山医院放射科;
【基金】：山东省医药卫生科技基金项目(2010K1304)
【分类号】：R446.5;R197.3
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本文编号：1980084