累积平均动脉压对全因死亡的预测价值

发布时间：2018-06-07 01:30

本文选题：累积平均动脉压 + 全因死亡　；参考：《中华高血压杂志》2016年11期

【摘要】：目的探讨累积平均动脉压(cumMAP)对全因死亡的预测价值。方法选择参加2006-2007、2008-2009及2010-2011年度健康体检且资料完整的开滦集团在职及离退休职工56 039人作为观察对象,进行了平均4.92年的随访,每年通过开滦社会保障信息系统获取死亡信息。cumMAP计算公式为[(MAP_1+MAP_2)/2×time_(1-2)]+[(MAP_2+MAP_3)/2×time_(2-3)],其中MAP_1、MAP_2、MAP_3分别为根据第1、2、3次体检血压值计算的平均动脉血压,time1-2、time2-3为相邻两次体检血压测量的时间间隔。将研究对象按cumMAP四分位分成4组,比较各组全因死亡率的差异,并采用多因素Cox比例风险模型分析cumMAP与全因死亡的关系。结果在平均4.92年随访期内共有1805例(3.2%)发生全因死亡。cumMAP第1~4四分位组全因死亡率分别为1.1%、2.3%、3.8%、5.6%(P0.01)。多因素Cox回归分析结果显示,在校正包括基线收缩压、平均动脉压在内的多种混杂因素后,与第1四分位组相比,第2、3、4四分位组发生全因死亡的HR值(95%CI)分别为1.17(0.95~1.43)、1.32(1.08~1.61)和1.34(1.09~1.65)。结论 cumMAP是全因死亡的独立危险因素。
[Abstract]:Objective to investigate the predictive value of cumMAPs for total death. Methods 56,039 workers of Kailuan Group who participated in the physical examination in 2006-2007, 2008-2009 and 2010-2011 and had complete data were selected as the observation objects. The average follow-up was 4.92 years. Death information was obtained from Kailuan Social Security Information system (Kailuan Social Security Information system). The formula of CumMAP was [MPA1 MAP_2)/2 脳 MAP_2)/2 _ (1-2)] [MP-MAP2 MAP_3)/2 脳 MAP_3)/2 _ (2 ~ 3)], where MAP1MAP2MAP2MAP3 is the mean arterial blood pressure (BP) time 1 ~ 2 ~ 2 ~ 3 calculated according to the blood pressure value of the first 2 ~ (th) physical examination, respectively, which is the time interval between the two adjacent physical examination blood pressure measurements. The subjects were divided into four groups according to cumMAP quartile. The differences of all-cause mortality were compared among each group. The multivariate Cox proportional risk model was used to analyze the relationship between cumMAP and all-cause death. Results during the mean follow-up period of 4.92 years, there were 1805 cases of total death. The total death rate of the 4th quartile group of CumMAP was 1.1 and 2.3%, respectively. The results of multivariate Cox regression analysis showed that after adjusting for various confounding factors including baseline systolic blood pressure and mean arterial pressure, compared with the 1st quartile group, the HR of the 2nd 3rd and 4th quartile group were 1.170.95 and 1.431.321.321.321.081.61and 1.340.09 / 1.65g, respectively. Conclusion cumMAP is an independent risk factor for all death.
【作者单位】：华北理工大学附属医院心内科;
【分类号】：R443.5

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