某院2529株细菌耐药性监测及分析

发布时间：2018-06-08 02:35

本文选题：全国细菌耐药监测网 + 细菌　；参考：《重庆医学》2016年36期

【摘要】：目的了解该院2014年临床分离细菌构成及对常用抗菌药物的敏感性和耐药性,为临床用药提供参考依据。方法收集2014年全年临床送检标本分离的细菌,采用PHOENIX全自动细菌鉴定药敏系统、全自动血液培养仪或手工方法进行分离鉴定,对临床分离细菌采用自动化仪器法或K-B纸片扩散法进行药物敏感试验,采用WHONT 5.6软件进行统计分析,按CLSI 2012年标准判定结果。结果共分离细菌2 529株,革兰阳性菌537株(21.23%),革兰阴性菌1 992株(78.77%)。葡萄球菌属中甲氧西林耐药株(MRSA和MRCNS)对测试药物的耐药率均显著高于甲氧西林敏感株(MSSA和MSCNS),已发现对替考拉宁耐药菌株;肠球菌属中屎肠球菌的分离率、耐药性大多数超过粪肠球菌,二者均存在万古霉素和替考拉宁耐药菌株;肠杆菌科细菌产ESBLs株对测试药物的耐药率均比非产ESBLs株高,对碳青霉烯类药物敏感性高;非发酵菌中鲍曼不动杆菌耐药性突出,明显高于铜绿假单胞菌。结论该院临床细菌耐药呈增长趋势,应定期进行耐药性监测并采取有效的控制措施,抑制细菌耐药,为临床用药提供参考。
[Abstract]:Objective to investigate the composition of clinical bacteria isolated in 2014 and the sensitivity and drug resistance to common antimicrobial agents in our hospital, and to provide reference for clinical use of antibiotics. Methods the bacteria isolated from clinical samples in 2014 were collected and identified by PHOENIX automatic bacteria identification system, automatic blood culture instrument or manual method. The drug sensitivity test was carried out by automatic instrument method or K-B disk diffusion method, and the statistical analysis was carried out by WHONT 5.6 software. The results were determined according to the CLSI 2012 standard. Results A total of 2 529 strains of bacteria were isolated, 537 strains of Gram-positive bacteria were isolated, and 1 992 strains of Gram-negative bacteria were isolated. The resistant rates of MRSA and MRCNS to the tested drugs were significantly higher than those of MSSA and MSCNSN in methicillin-sensitive strains. Teicoplanin resistant strains were found to be resistant to teicoplanin, and Enterococcus faecium was isolated from Enterococcus faecium. The drug resistance of Enterococcus faecalis was higher than that of Enterococcus faecalis, both of them were vancomycin and teicoplanin resistant strains, and the resistance rate of ESBLs producing strains of Enterobacteriaceae was higher than that of non-ESBLs producing strains, and the susceptibility to carbapenems was higher than that of non-ESBLs strains. The antimicrobial resistance of Acinetobacter baumannii was higher than that of Pseudomonas aeruginosa. Conclusion the clinical drug resistance of bacteria in our hospital is on the increase. It is necessary to monitor drug resistance regularly and take effective control measures to inhibit bacterial drug resistance and to provide reference for clinical use of drugs.
【作者单位】：贵州省黔西南州人民医院院感科;贵州省黔西南州人民医院检验科;
【基金】：贵州省黔西南州科技计划项目(2014.26)
【分类号】：R446.5

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