广州地区新生儿败血症和脑膜炎B族链球菌分离株药敏分析

发布时间：2018-06-12 19:31

本文选题：新生儿 + B族链球菌　；参考：《广东医学》2016年12期

【摘要】：目的了解广州地区新生儿B族链球菌(GBS)败血症和脑膜炎的感染现状及分离株药敏特征。方法收集新生儿血培养和脑脊液培养分离的GBS菌株,并分析其药敏特征及感染患儿年龄分布情况。结果共分离到GBS菌株49株,其对抗菌药物耐药率由高到低分别是四环素98.0%(48/49)、红霉素63.27%(31/49)、克林霉素59.18%(29/49)、环丙沙星11.90%(5/42)、莫西沙星12.20%(5/41)、氧氟沙星7.69%(2/26),对β内酰胺类抗生素包括青霉素、头孢曲松、氨苄西林、头孢呋新钠、头孢克罗、头孢唑啉未见耐药,对其他5种抗菌药物如利奈唑烷、喹奴普汀/达福普汀、氯霉素、万古霉素、呋喃妥因均全部敏感,49例GBS败血症和(或)脑膜炎患儿中,早发型感染占30.61%。结论新生儿血液和脑脊液GBS分离株对四环素几乎100%耐药,对红霉素和克林霉素耐药率约为60%,对喹诺酮类耐药率较低,对β内酰胺类抗生素和其他抗菌药物均未见耐药,可为新生儿GBS败血症和脑膜炎感染治疗提供用药参考。
[Abstract]:Objective to investigate the status of septicemia and meningitis in newborns of Group B Streptococcus B in Guangzhou. Methods GBS strains isolated from neonatal blood culture and cerebrospinal fluid culture were collected and their drug sensitivity and age distribution were analyzed. Results A total of 49 strains of GBS were isolated. The drug resistance rates of GBS strains from high to low were tetracycline 98.0 and 48 / 49, erythromycin 63.27 / 49, clindamycin 59.18 / 49, ciprofloxacin 11.90 / 5 / 42, moxifloxacin 12.20 / 541%, ofloxacin 7.69% 26%, 尾 -lactam antibiotics including penicillin, ceftriaxone, Ampicillin, cefuroxime sodium, cefaclor, cefazolin, cefazolin were not resistant to 5 other antimicrobial agents such as linazolane, quinuptin / dafoputin, chloramphenicol, vancomycin, In 49 cases of GBS septicemia and / or meningitis, early infection accounted for 30. 61%. Conclusion Neonatal blood and cerebrospinal fluid GBS isolates are nearly 100% resistant to tetracycline, about 60% to erythromycin and clindamycin, and less resistant to quinolones, but not resistant to 尾 -lactam antibiotics and other antibiotics. It can provide drug reference for the treatment of neonatal GBS septicemia and meningitis infection.
【作者单位】：广东省广州市妇女儿童医疗中心检验科微生物室;
【基金】：广州市医药卫生一般引导项目(编号:2013A011040022)
【分类号】：R722.131;R446.5

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