992株临床分离病原菌分布及耐药性分析

发布时间：2018-06-15 02:26

本文选题：革兰阴性菌 + 革兰阳性菌　；参考：《重庆医学》2016年34期

【摘要】：目的了解该院近3年临床分离病原菌的分布及耐药情况。方法回顾性分析该院2011年11月至2014年12月临床分离的992株病原菌及药敏结果。结果该院992株病原菌中革兰阴性杆菌487株(49.1%),大肠埃希菌和肺炎克雷伯菌产ESBLs检出率分别为47.5%、16.7%,两者对亚胺培南和美洛培南的敏感率分别为100%、98.5%;铜绿假单胞菌、鲍曼不动杆菌对多种抗菌药物高度敏感;嗜麦芽窄食假单胞菌对多种抗菌药物均有不同程度的耐药,但对复方黄胺甲VA唑100%敏感。革兰阳性球菌245株(24.7%),耐甲氧西林金黄色葡萄球菌、耐甲氧西林凝固酶阴性葡萄球菌的检出率分别为45.5%、91.6%,未检出耐万古霉素葡萄球菌和耐万古霉素肠球菌。真菌260株(26.2%),白假丝酵母菌对抗真菌药高度敏感,热带假丝酵母菌的耐药率较高。结论定期回顾分析临床分离病原菌的分布及其耐药性,有利于及时掌握其耐药性的变迁,从而指导临床合理应用抗菌药物。
[Abstract]:Objective to investigate the distribution and drug resistance of pathogenic bacteria isolated in our hospital in recent 3 years. Methods 992 strains of pathogenic bacteria from November 2011 to December 2014 were retrospectively analyzed. Results among the 992 strains of pathogenic bacteria, 487 strains of Gram-negative bacilli were found to be Gram-negative bacilli. The positive rates of ESBLs produced by Escherichia coli and Klebsiella pneumoniae were 47.5% and 16.7g, respectively. The sensitivity rates of the two strains to imipenem and meropenem were 100% and 98.5, respectively, and Pseudomonas aeruginosa. Acinetobacter baumannii was highly sensitive to many antimicrobial agents, and Pseudomonas maltophilia was resistant to various antibiotics to varying degrees, but was sensitive to 100% of compound flavanazole. There were 245 strains of Gram-positive cocci, methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative staphylococcus were 45.5% and 91.6%, respectively. No vancomycin resistant staphylococcus and vancomycin resistant Enterococcus were detected. 260 strains of Candida cerevisiae were highly sensitive to antifungal agents, and the resistance rate of Candida tropicalis was higher than that of Candida tropicalis. Conclusion to analyze the distribution and drug resistance of pathogenic bacteria in clinical isolation periodically is helpful to grasp the changes of drug resistance in time and to guide the rational use of antimicrobial agents in clinic.
【作者单位】：重庆医科大学附属大学城医院检验科;
【分类号】：R446.5

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