399株医院真菌感染的分布特点及耐药性分析

发布时间：2018-06-18 01:33

本文选题：医院真菌 + 药物敏感试验　；参考：《首都医科大学学报》2016年04期

【摘要】：目的了解本院临床常见真菌的种类及常用抗真菌药物的耐药情况,为临床合理使用抗真菌药物提供依据。方法对2014年1月至2015年12月临床采集的标本进行真菌分离培养,采用科玛嘉念珠菌显色培养基及API 20C AUX酵母菌鉴定试剂盒进行真菌鉴定,ATB Fungus 3药敏试剂盒进行药敏试验,统计分析菌种的构成及其对5种抗真菌药物的敏感率。结果共收集培养得到399株真菌,标本类型以尿液为主,念珠菌中以白色假丝酵母菌为主,共188株,占47.1%;丝状真菌中以烟曲霉菌为主,共25株,占6.3%。白色念珠菌对抗真菌药物的敏感性较好,大部分在95%以上,但光滑念珠菌对唑类药物敏感性相对较低,对氟康唑的敏感性只有65.1%。曲霉菌对两性霉素B、伊曲康唑和伏立康唑均有着较高的敏感性。结论医院真菌感染以白色念珠菌为主,两性霉素B和5-氟胞嘧啶对其有较高的抗菌活性;光滑念珠菌对唑类药物有较高的耐药性,临床应根据药敏结果合理使用抗真菌药物。
[Abstract]:Objective to understand the types of common fungi and the drug resistance of common antifungal drugs in our hospital in order to provide the basis for the rational use of antifungal drugs. Methods the specimens collected from January 2014 to December 2015 were isolated and cultured. The coloration culture medium of Candida albicans and the API 20C AUX yeast identification kit were carried out. Fungi identification, ATB Fungus 3 drug sensitive kit for drug sensitivity test, statistical analysis of the composition of bacteria and the sensitivity of the 5 antifungal drugs. Results a total of 399 strains of fungi were collected and cultured, specimen types were mainly urine, Candida albicans were mainly Candida albicans, a total of 188 strains, accounting for 47.1%. Filamentous fungi were mainly Aspergillus fumigatus, a total of 25 The sensitivity of 6.3%. Candida albicans against fungal drugs was better, most of them were more than 95%, but the sensitivity of Candida smooth Candida to azolic drugs was relatively low. The sensitivity to fluconazole was higher than that of amphotericin B, itraconazole and voriconazole by 65.1%. Aspergillus. Conclusion the nosocomial fungal infection is white beads. The bacteria are mainly bacteria, amphotericin B and 5- fluorcytosine have high antimicrobial activity. Candida smooth bacteria have high resistance to azolics, and antifungal drugs should be used in the clinic according to the result of drug sensitivity.
【作者单位】：首都医科大学附属北京地坛医院检验科;
【基金】：北京市优秀人才培养资助(2014000021469G235)~~
【分类号】：R446.5

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