2003-2013年金黄色葡萄球菌临床分布与耐药率变迁

发布时间：2018-06-18 07:22

本文选题：金黄色葡萄球菌 + 抗菌药物　；参考：《中华医院感染学杂志》2016年04期

【摘要】：目的调查分析医院分离的金黄色葡萄球菌分布及耐药率变迁,为临床合理使用抗菌药物提供依据。方法收集2003-2013年从临床各种标本分离的金黄色葡萄球菌,每年随机挑取60株进行分析,共660株,菌种鉴定采用全自动微生物分析仪,按照美国临床实验室标准化研究所推荐的标准进行结果解释。结果 660株金黄色葡萄球菌主要分离自痰液标本占55.8%;金黄色葡萄球菌中检出耐甲氧西林金黄色葡萄球菌(MRSA)386株,检出率58.5%;MRSA的检出率2009-2013年低于2003-2008年;2003-2013年MRSA对红霉素的耐药率均80.0%,对环丙沙星和克林霉素的耐药率均70.0%,而对四环素、庆大霉素、利福平和氯霉素的耐药率分别为59.3%~90.7%、44.4%~100.0%、20.7%~91.3%和3.7%~33.3%。结论 MRSA检出率和金黄色葡萄球菌对常用抗菌药物的耐药率呈下降趋势。
[Abstract]:Objective to investigate and analyze the distribution of Staphylococcus aureus isolated in hospital and the change of drug resistance rate so as to provide evidence for rational use of antimicrobial agents in clinic. Methods from 2003 to 2013, 60 strains of Staphylococcus aureus isolated from clinical specimens were randomly selected for analysis. The results were interpreted according to the criteria recommended by the American Institute of Clinical Laboratory Standardization. Results 660 strains of Staphylococcus aureus were mainly isolated from sputum and 386 strains of methicillin-resistant Staphylococcus aureus were detected. The detection rate of MRSA in 2009-2013 was lower than that of MRSA in 2003-2008. The resistance rate of MRSA to erythromycin was 80.03%, and to ciprofloxacin and clindamycin was 70.0.The resistant rates to tetracycline, gentamycin, rifampicin and chloramphenicol were 59.30.7% and 3.733.33%, respectively. Conclusion the detection rate of MRSA and the resistance rate of Staphylococcus aureus to common antimicrobial agents are decreasing.
【作者单位】：温州医科大学附属第一医院检验科;温州医科大学附属第一医院呼吸科;
【基金】：国家自然科学基金资助项目(81271906H2002) 温州市科技计划基金资助项目(Y20130239)
【分类号】：R446.5

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