2014年湖北省秭归县人民医院细菌耐药性监测

发布时间：2018-06-19 19:52

  本文选题：细菌 + 耐药监测　； 参考：《中国感染与化疗杂志》2016年01期

【摘要】：目的了解2014年湖北省秭归县人民医院临床分离细菌对抗菌药物的耐药性。方法采用纸片扩散法(K-B法)对细菌作药物敏感性试验,以2014年版CLSI标准判断结果,采用WHONET 5.6软件统计分析。结果总计1 338株细菌,革兰阳性菌和革兰阴性菌分别占27.2%和72.8%。金黄色葡萄球菌和凝固酶阴性葡萄球菌耐甲氧西林菌株检出率分别为30.4%和66.7%,肺炎链球菌青霉素敏感、中介和耐药菌株各占64.9%、24.3%和10.8%。葡萄球菌和肺炎链球菌中未发现万古霉素、替考拉宁和利奈唑胺耐药株;屎肠球菌出现1株万古霉素耐药株。肠杆菌科细菌对碳青霉烯类抗生素仍高度敏感,但耐药菌株亦已出现。大肠埃希菌和克雷伯菌属产超广谱β内酰胺酶的检出率分别为58.3%和31.3%。大肠埃希菌对亚胺培南和美罗培南的耐药率为0和0.4%;肺炎克雷伯菌对亚胺培南和美罗培南的耐药率均为1.7%;鲍曼不动杆菌对亚胺培南和美罗培南的耐药率为19.3%和32.1%;铜绿假单胞菌对亚胺培南和美罗培南耐药率为0.9%和1.8%。广泛耐药(XDR)菌株5株,为鲍曼不动杆菌、弗氏枸橼酸杆菌、大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌各1株。结论革兰阳性菌(除屎肠球菌1株耐万古霉素外)未发现万古霉素、替考拉宁和利奈唑胺耐药株;革兰阴性杆菌对碳青霉烯类抗生素高度敏感,但耐药菌株亦已出现。随着医疗设施不断完善和提高,拟将2级医院纳入全国细菌耐药监测网,夯实网底建设,防止细菌耐药性加剧。
[Abstract]:Objective to investigate the antimicrobial resistance of clinical bacteria isolated from Zigui County Hospital of Hubei Province in 2014. Methods the drug sensitivity of bacteria was tested by disk diffusion method (K-B method). The results of CLSI criteria of 2014 edition were analyzed by WHONET 5.6 software. Results A total of 1 338 strains of bacteria, gram-positive bacteria and gram-negative bacteria accounted for 27.2% and 72.8%, respectively. The positive rates of methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococcus were 30.4% and 66.7%, respectively. Streptococcus pneumoniae was sensitive to penicillin, and the intermediate and resistant strains accounted for 64.9% and 10.8%, respectively. Vancomycin, teicoplanin and linazolamide resistant strains were not found in Staphylococcus and Streptococcus pneumoniae, and one vancomycin resistant strain was found in Enterococcus faecium. Enterobacteriaceae bacteria are still highly sensitive to carbapenem antibiotics, but drug-resistant strains have also appeared. The detection rates of extended-spectrum 尾 -lactamases produced by Escherichia coli and Klebsiella were 58.3% and 31.3%, respectively. The resistance rates of Escherichia coli to imipenem and meropenem were 0 and 0.4, those of Klebsiella pneumoniae to imipenem and meropenem were 1.7, those of Acinetobacter baumannii to imipenem and meropenem were 19.3% and 32.1%, respectively. The resistance rates of Pseudomonas aeruginosa to imipenem and meropenem were 0.9% and 1.8% respectively. Five XDRs were found to be Acinetobacter baumannii, Citrobacter flexneri, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. Conclusion No vancomycin, teicoplanin and linazolamide resistant strains were found in Gram-positive bacteria (except one of Enterococcus faecium), and Gram-negative bacilli were highly sensitive to carbapenem antibiotics, but resistant strains were also found. With the continuous improvement and improvement of medical facilities, it is proposed that level 2 hospitals be incorporated into the national bacterial drug resistance monitoring network to consolidate the construction of the bottom of the network to prevent the aggravation of bacterial drug resistance.
【作者单位】： 湖北省秭归县人民医院检验科;湖北省秭归县梅家河乡卫生院;湖北省秭归县杨林桥镇卫生院;湖北省秭归县两河镇卫生院;
【分类号】：R446.5
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本文编号：2041066