老年医学科患者艰难梭菌检测结果与定植危险因素分析

发布时间：2018-06-21 08:15

本文选题：艰难梭菌 + 危险因素　；参考：《中华医院感染学杂志》2016年10期

【摘要】：目的研究医院老年医学科患者粪便中艰难梭菌的检出率,并分析定植危险因素,为制定有效的预防与控制措施提供理论依据。方法 2014年12月14日开展横断面调查,留取老年医学科78例住院患者的粪便标本,用选择性培养基进行厌氧培养,并利用多重PCR技术进行艰难梭菌毒素基因检测,同时收集所有患者的临床资料,进行艰难梭菌定植高危因素分析;采用SPSS18.0软件进行统计分析。结果 78例患者中艰难梭菌培养阳性36例,阳性率46.15%,均为无症状携带患者;36株艰难梭菌中有tcdA+/tcdB+基因14株占38.89%,tcdA-/tcdB-基因18株占50.00%,tcdA-/tcdB+基因4株占11.11%;患者年龄、住院日、1个月内鼻饲管及抗菌药物的使用为其定植高危因素。结论医院老年医学科住院患者艰难梭菌定植率高,年龄、住院日、1个月内鼻饲管及抗菌药物的使用为其定植高危因素。
[Abstract]:Objective to study the detection rate of Clostridium difficulty in feces of geriatrics patients in hospital and analyze the risk factors of colonization so as to provide theoretical basis for effective prevention and control measures. Methods A cross-sectional investigation was carried out on December 14, 2014. Fecal specimens of 78 inpatients in geriatrics department were collected, and anaerobic culture was carried out on selective culture medium. At the same time, the clinical data of all patients were collected, and the high risk factors of Clostridium difficulty colonization were analyzed, and SPSS 18.0 software was used for statistical analysis. Results among the 78 patients, 36 were positive in culture of Clostridium difficulty, the positive rate was 46.15. All of the 36 strains of Clostridium difficulty were asymptomatic carriers with 14 strains of tcdA / TcdB gene (38.89%), 18 strains of 18 strains of TcdA-R / TcdB- gene accounted for 50.00tcdA-rtcdB gene 4 strains (11.1111%), and the age of the patients was 11.11%. The high risk factors of colonization were the use of nasal feeding tube and antimicrobial drugs within 1 month. Conclusion the high colonization rate, age, length of stay, and the use of nasal feeding tube and antimicrobial agents in geriatric department of hospital are the high risk factors for colonization.
【作者单位】：宁波市第二医院感染内科;杭州市疾病预防控制中心;宁波市第二医院老年医学科;
【基金】：浙江省区域专病中心建设学科基金资助项目(2014-98)
【分类号】：R440

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