MRI评价肝细胞癌组织学分化程度的价值

发布时间：2018-06-23 05:43

本文选题：磁共振成像 + 肝细胞癌　；参考：《中山大学学报(医学科学版)》2016年06期

【摘要】：【目的】通过分析肝细胞癌(HCC)MRI的主要征象与不同组织学分化程度之间的关系,探讨MRI在评价肝细胞癌组织学分化程度中的价值。【方法】将病理证实的229例HCC分为3组:高分化组(34例),中分化组(170例),低分化组(25例)。均行常规MRI及DWI检查,分析HCC瘤灶主要征象与HCC组织学分化程度的关系。【结果】229例HCC中(1)HCC瘤灶的分叶程度与组织学分化程度之间呈较弱的负相关关系(r=-0.37,P=0.000);HCC的T1WI信号强度与组织学分化程度之间呈较弱的正相关关系(r=0.292,P=0.000);HCC的T2WI信号强度与组织学分化程度之间呈较弱的负相关关系(r=-0.207,P=0.002)。HCC的DWI目测信号强度与组织学分化程度之间呈较弱的负相关关系(r=-0.317,P=0.000)。(2)HCC的"包膜"完整性,血供方式与组织学分化程度之间无显著相关关系(P0.05)。(3)在HCC瘤灶的分叶程度、T1WI信号强度、T2WI信号强度和DWI目测信号强度中,HCC瘤灶的分叶程度是影响组织学分化程度的最显著因素(OR1=0.15,OR2=0.25,P0.05)。【结论】MRI中HCC的分叶程度、T1WI、T2WI、DWI的目测信号强度有利于预测HCC组织学分化程度,其中HCC分叶程度为最主要的征象;然而,根据常规MRI检查及DWI的目测信号强度,而正确预测HCC的组织学分化程度是有限的,应该综合多种征象分析。
[Abstract]:[objective] to analyze the relationship between MRI features and histological differentiation of hepatocellular carcinoma (HCC). Methods 229 cases of HCC confirmed by pathology were divided into 3 groups: high differentiation group (34 cases), moderate differentiation group (170 cases) and low differentiation group (25 cases). All patients were examined by conventional MRI and DWI. [results] in 229 cases of HCC, there was a weak negative correlation between the degree of lobulation and the degree of histological differentiation (r-0.37 P0. 000). [results] in 229 cases of HCC, there was a weak negative correlation between the signal intensity on T 1WI and histological differentiation. There was a weak positive correlation between the degree of T2WI and the degree of histological differentiation. There was a weak negative correlation between the signal intensity of T2WI and the degree of histological differentiation (r-0.207 P0. 002). There was a weak negative correlation between the visual signal intensity of HCC and the degree of histological differentiation (r-0.317P0.000). (2). There was no significant correlation between blood supply pattern and histological differentiation (P0.05). The most important factor affecting histological differentiation was the signal intensity of T1WI and visual signal intensity of T2WI. [conclusion] the lobular degree of HCC in MRI and the visual signal intensity of T1WIT T2WI DWI are helpful to predict the degree of histological differentiation of HCC. However, according to conventional MRI and DWI visual signal intensity, it is limited to correctly predict the degree of histological differentiation of HCC.
【作者单位】：中山大学附属第三医院放射科;中山大学附属第五医院;
【基金】：国家自然科学基金(81430041)
【分类号】：R445.2;R735.7

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