5937例结核病患者非结核分枝杆菌感染及其对抗结核药物耐药情况分析

发布时间：2018-06-25 12:31

本文选题：非结核分枝杆菌 + 结核病　；参考：《山东医药》2016年12期

【摘要】：目的分析结核病患者非结核分枝杆菌(NTM)感染及其对抗结核药物耐药情况。方法研究对象为2008~2014年青岛市胸科医院收治的5 937例结核病患者,从其痰液、支气管灌洗液、胸腔积液、腹腔积液、胸壁组织、脓液、分泌物、脑脊液、尿液、粪便等标本分离培养出分枝杆菌5 937株;采用生化反应法进行NTM菌种鉴定;采用罗氏培养基为基础的绝对浓度法进行NTM对异烟肼(INH)、链霉素(SM)、利福平(RFP)、乙胺丁醇(EMB)、对氨基水杨酸(PAS)、阿米卡星(AMK)、丙硫异烟胺(TH)、左氧氟沙星(LOFL)、力克肺疾(PNA)9种抗结核药物的药敏试验。结果 2008~2014年NTM总检出率为2.86%(170/5 937),2012年检出率最低为1.80%(15/831),2010年检出率最高为3.62%(27/746)。NTM对INH的耐药率为92.35%、PAS为91.76%、PNA为78.82%、TH为73.52%、EMB为67.05%、LOFL为63.52%、SM为50.58%、RFP为45.88%、AMK为31.76%。结论结核病患者中NTM检出率较高(2.86%),对常用抗结核药物耐药率亦较高。
[Abstract]:Objective to analyze the non-tuberculosis mycobacterium (NTM) infection and its anti-tuberculosis drug resistance in patients with tuberculosis. Methods from 2008 to 2014, 5,937 patients with tuberculosis were treated in Qingdao chest Hospital. Sputum, bronchial lavage fluid, pleural effusion, celiac effusion, chest wall tissue, pus, secretion, cerebrospinal fluid and urine were studied. 5937 strains of Mycobacterium were isolated from feces and other specimens, and the strains of NTM were identified by biochemical reaction. Nine antituberculous effects of NTM on isoniazid (INH), streptomycin (SM), rifampicin (RFP), ethambutanol (EMB), p-aminosalicylic acid (pas), amikacin (AMK), propyleneisoniamin (th), levofloxacin (LOFL), rifampicin (RFP), aminosalicylic acid (pas), amicacin (AMK), propylenionomine (th), levofloxacin (LOFL), and lung disease (PNA) were studied using the absolute concentration method based on Roche medium. Drug sensitivity test. Results the total detection rate of NTM in 2008 ~ 2014 was 2.86% (170 / 5,937), the lowest was 1.80% (15 / 831) in 2012, and the highest detection rate was 3.62% (27 / 746) in 2010. The resistance rate of NTM to INH was 92.35% (27 / 746). Conclusion the positive rate of NTM in tuberculosis patients is high (2.86%), and the rate of resistance to common anti-tuberculosis drugs is also high.
【作者单位】：青岛市胸科医院;青岛大学医学院第二附属医院;山东大学齐鲁医院;
【分类号】：R446.5;R52

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