早期肠内营养预防重型颅脑损伤病人应激性溃疡的临床研究

发布时间：2018-06-28 06:55

本文选题：重型颅脑损伤 + 肠内营养　；参考：《肠外与肠内营养》2016年03期

【摘要】：目的:探讨早期肠内营养(EEN)对重型颅脑损伤病人应激性溃疡的预防价值。方法:分析我院85例神经外科重症监护病房收住的重型颅脑损伤病人。将病人分为EEN组和抑酸药组。分析两组病人年龄、性别、GCS评分、水电解质紊乱、凝血功能障碍、高血糖、多发伤、肺部感染、死亡、颅内感染、应激性溃疡及预后等参数。分析抑酸药物的使用与肺部感染发生之间的相关性。结果:EEN组与抑酸药组应激性溃疡的发生无统计学差异(P0.05);肺部感染发生率有显著性差异(P0.05)。抑酸药物的使用与肺部感染存在显著的相关性(r=0.253,P=0.019)。两组病人血清前清蛋白、转铁蛋白、上臂周径、预后等方面均有显著性差异(P0.05)。结论:重型颅脑损伤病人EEN不仅可以预防应激性溃疡的发生,而且还可减少肺部感染的发生率,改善病人的营养状况和预后。
[Abstract]:Objective: to investigate the value of early enteral nutrition (EEN) in the prevention of stress ulcer in patients with severe craniocerebral injury. Methods: 85 patients with severe craniocerebral injury in neurosurgical intensive care unit were analyzed. Patients were divided into EEN group and acid suppressant group. Age, sex and GCS score, water electrolyte disturbance, coagulation dysfunction, hyperglycemia, multiple injury, pulmonary infection, death, intracranial infection, stress ulcer and prognosis were analyzed. To analyze the correlation between the use of acid suppressants and pulmonary infection. Results there was no significant difference in the incidence of stress ulcer between the two groups (P0.05), but the incidence of pulmonary infection was significantly different (P0.05). There was a significant correlation between the use of anti-acid drugs and pulmonary infection (r = 0.253). There were significant differences in serum prealbumin transferrin upper arm circumference and prognosis between the two groups (P0.05). Conclusion: EEN in patients with severe craniocerebral injury can not only prevent the occurrence of stress ulcer, but also reduce the incidence of pulmonary infection and improve the nutritional status and prognosis of the patients.
【作者单位】：南方医科大学南方医院神经外科;南方医科大学南方医院营养科;
【基金】：黎介寿院士肠道屏障专项研究基金
【分类号】：R459.3;R651.15

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