综合护理干预对糖尿病足溃疡面修复相关因子的影响

发布时间：2018-07-01 11:39

本文选题：综合护理 + 糖尿病足　；参考：《实用医学杂志》2016年16期

【摘要】：目的:探讨综合护理干预对糖尿病足溃疡愈合及创面修复因子的调控作用。方法:40例糖尿病足溃疡患者随机分为对照组和护理干预组,各20例,对照组采用内科常规护理,干预组采用湿润烧伤膏外敷换药和综合强化护理,比较两组患者在溃疡愈合速度、时间、换药次数、时间及疗效方面的差异,并检测各时间段肉芽组织中创伤修复因子的表达量。结果:干预组在换药次数、时间,创面愈合时间上均明显少于对照组(P0.05);干预4周后,干预组疗效明显优于对照(P=0.00);干预组在第14、21、28天的b FGF、EGF、VEGF、PDGF、AEGs表达量与对照组比较,差异具有统计学意义(P0.05)。结论 :综合护理干预能有效提高糖尿病足溃疡治疗的疗效,并能促进创面愈合修复因子b FGF、EGF、VEGF、PDGF的表达,抑制负性因子AEGs的生成。
[Abstract]:Objective: to investigate the effect of comprehensive nursing intervention on diabetic foot ulcer healing and wound healing factors. Methods 40 patients with diabetic foot ulcer were randomly divided into two groups: control group (n = 20) and nursing intervention group (n = 20). The healing speed, time, times, time and curative effect of ulcer healing were compared between the two groups, and the expression of wound repair factor in granulation tissue was detected. Results: the times, times and healing time of wound healing in the intervention group were significantly less than those in the control group (P0.05), the curative effect in the intervention group was significantly better than that in the control group after 4 weeks of intervention (P < 0.05), the expression of bFGFEGFVEGFU PDGFGF-AEGs in the intervention group was significantly higher than that in the control group on the 28th day after intervention (P < 0.05). The difference was statistically significant (P0.05). Conclusion: comprehensive nursing intervention can effectively improve the therapeutic effect of diabetic foot ulcer, promote the expression of bFGF- EGFV EGFU PDGF, and inhibit the production of negative factor AEGs.
【作者单位】：深圳市龙华新区中心医院;广东省中医院;
【基金】：广东省深圳市宝安区科技计划公益项目(编号:2012286)
【分类号】：R473.5

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