皮肤软组织感染的病原菌分布与耐药性分析

发布时间：2018-07-05 05:49

本文选题：皮肤软组织感染 + 细菌分布　；参考：《中国临床药理学杂志》2016年11期

【摘要】：目的了解皮肤软组织感染细菌的分布及耐药状况。方法收集2010—2014年北京大学第一医院门诊和住院患者的皮肤软组织感染标本,常规方法进行细菌培养和鉴定,按纸片法、微量稀释法或E-test法测定细菌药物敏感性。结果共分离出非重复细菌1793株,排在前4位的依次是金黄色葡萄球菌、表皮葡萄球菌、大肠埃希菌和铜绿假单胞菌,分别占32.6%,10.7%,10.7%,10.3%。甲氧西林敏感金黄色葡萄球菌(MSSA)分离率多年来一直居首位。未检出万古霉素耐药金黄色葡萄球菌和表皮葡萄球菌,对利奈唑胺耐药率分别为0.2%和0。大肠埃希菌和铜绿假单胞菌对亚胺培南的耐药率分别为0和13.6%。结论皮肤软组织感染的主要致病菌仍以金黄色葡萄球菌为主。
[Abstract]:Objective to investigate the distribution and drug resistance of bacteria infected with skin and soft tissue. Methods the samples of skin and soft tissue infection from outpatients and inpatients in the first Hospital of Peking University from 2010 to 2014 were collected. The bacteria were cultured and identified by routine methods. The bacterial susceptibility was determined by paper method, microdilution method or E-test method. Results A total of 1793 strains of non-repetitive bacteria were isolated. Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli and Pseudomonas aeruginosa were ranked in the first four places, accounting for 32.6% 10.7% and 10.7% respectively. The isolation rate of methicillin sensitive Staphylococcus aureus (MSSA) has been the highest for many years. Vancomycin resistant Staphylococcus aureus and Staphylococcus epidermidis were not detected and the resistant rates of vancomycin resistant Staphylococcus aureus and Staphylococcus epidermidis were 0.2% and 0.2% respectively. The resistance rates of Escherichia coli and Pseudomonas aeruginosa to imipenem were 0 and 13.6respectively. Conclusion Staphylococcus aureus is the main pathogen of skin soft tissue infection.
【作者单位】：北京大学第一医院检验科;北京大学第一医院整形烧伤科;北京大学第一医院临床药理研究所;北京大学第一医院普通外科;
【基金】：国家科技支撑计划基金资助项目(2012EP001002) 中国医药卫生事业发展基金会课题基金资助项目
【分类号】：R446.5

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