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颈动脉狭窄致脑低灌注损伤多模态MRI

发布时间:2018-07-05 18:05

  本文选题:颈动脉 + 动脉病变 ; 参考:《放射学实践》2016年04期


【摘要】:目的:探讨颈动脉狭窄程度与颈内动脉血流动力学参数及相关脑区ADC值变化的关系。方法:27例患者经磁共振血管成像(MRA)证实有中度以上颈动脉狭窄。所有患者行颅脑常规MRI、MRA和DWI检查,并采用血流定量测量(QFlow)和彩色多普勒超声(CDFI)对颈内动脉的血流动力学参数进行分析。对QFlow技术与CDFI测量的血流参数(血流量、平均流速、峰值流速及管腔面积)及其与颈动脉狭窄程度及相关脑区的表观扩散系数值(ADC)之间的相关性行非参数检验。结果:1QFlow技术与CDFI测量的血流量和平均流速呈中度正相关(r=0.695,P0.01;r=0.795,P0.01),峰值流速和管腔面积呈低度正相关(r=0.453,P0.01;r=0.573,P0.01)。2颈动脉狭窄程度与QFlow技术测量的颈内动脉流量呈低度负相关(r=-0.467,P0.01),与侧脑室旁前部和额叶白质的ADC值呈低度正相关(r=0.373,P0.01;r=0.372,P0.01)。3侧脑室旁前部和额叶白质的ADC值与QFlow技术测量的颈内动脉流量分别呈中度和低度负相关(r=-0.624,P0.01;r=-0.533,P0.01)。结论:多模态MRI能显示颈动脉狭窄所致的颈内动脉血流量减低及供血脑区的低灌注损伤,QFlow技术能较准确评价颈内动脉血流动力学变化。
[Abstract]:Objective: to investigate the relationship between carotid stenosis and internal carotid artery hemodynamic parameters and ADC values in related brain regions. Methods 27 patients with moderate carotid artery stenosis were confirmed by magnetic resonance angiography (MRA). All patients were examined with conventional MRI MRA and DWI, and the hemodynamic parameters of internal carotid artery were analyzed by quantitative blood flow measurement (QFlow) and color Doppler ultrasound (CDFI). The blood flow parameters (blood flow, mean velocity, peak velocity and lumen area) measured by QFlow and CDFI, and their correlation with carotid stenosis and apparent diffusion coefficient (ADC) of the related brain region were examined by non-parametric test. Results the blood flow and mean flow velocity measured by CDFI were positively correlated (r 0.695U P 0.01n 0.795g P 0.01), the peak flow velocity was positively correlated with the lumen area (r 0.453P 0.01U 0.573P 0.01) .2 the degree of carotid artery stenosis was negatively correlated with the internal carotid artery flow measured by QFlow technique (r = -0.467P 0.01), and was negatively correlated with the flow of the internal carotid artery measured by QFlow technique (r = 0.467P 0.01), while the peak flow velocity was positively correlated with the lumen area (r = 0.453P 0.01n 0.573P 0.01). The ADC values of the anterior and frontal white matter of the paraventricular and frontal lobes showed a low positive correlation (r = 0.373U, P 0.01, P = 0.372P 0.01). 3 the ADC values of the anterior and frontal white matter of the paraventricular and frontal lobes were negatively correlated with the internal carotid artery flow measured by QFlow (r -0.624, P 0.01, P 0.01, P 0.01). Conclusion: multimodal MRI can accurately evaluate the changes of internal carotid artery hemodynamics by using QFlow technique to show the decrease of internal carotid artery blood flow caused by carotid stenosis and the low perfusion injury in the supplying brain area.
【作者单位】: 大连市第五人民医院放射科;大连市第五人民医院介入科;
【基金】:大连市科学技术局资助项目(2013E15SF151)
【分类号】:R445.2;R543.4

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