血液肿瘤患者感染病原菌分布与耐药性研究

发布时间：2018-07-12 10:22

本文选题：血液肿瘤 + 患者　；参考：《中华医院感染学杂志》2016年04期

【摘要】：目的探讨血液肿瘤患者感染病原菌的分布及耐药性,为选择合适的抗菌药物提供依据。方法回顾性分析2009年7月-2012年7月医院1 249例血液肿瘤患者临床资料,对其血液样本的采集、培养的病原菌进行鉴定,并分析其病原菌的分布及耐药性。结果 1 249例患者血培养标本分离出病原菌127株,其中革兰阴性菌89株占66.9%,以大肠埃希菌34株26.8%、铜绿假单胞菌16株12.6%、肺炎克雷伯菌15株11.8%为主,革兰阳性菌36株占28.3%,以表皮葡萄球菌11株8.7%、金黄色葡萄球菌8株6.3%、屎肠球菌6株4.7%为主,真菌7株占4.8%,以热带假丝酵母菌4株3.2%为主;大肠埃希菌对亚胺培南的耐药率为100.0%,铜绿假单胞菌对阿米卡星的耐药率为93.8%,肺炎克雷伯菌对亚胺培南的耐药率为100.0%,表皮葡萄球菌、金黄色葡萄球菌对利奈唑胺、万古霉素、喹奴普汀/达福普汀的耐药率均为100.0%。结论血液肿瘤患者感染的病原菌种类较多、耐药率较高,做好病原菌耐药性及时监测和抗菌药物的正确选择,对控制血液感染起着非常重要的影响。
[Abstract]:Objective to investigate the distribution and drug resistance of pathogenic bacteria in blood tumor patients, and to provide evidence for the selection of appropriate antimicrobial agents. Methods the clinical data of 1 249 patients with blood tumor in hospital from July 2009 to July 2012 were retrospectively analyzed. The blood samples were collected and the pathogenic bacteria cultured were identified, and the distribution and drug resistance of the pathogens were analyzed. Results 127 strains of pathogenic bacteria were isolated from blood samples of 1,249 patients, of which 89 strains were Gram-negative bacteria (69. 9%), 34 were Escherichia coli (26. 8), 16 were Pseudomonas aeruginosa (12. 6) and 15 were Klebsiella pneumoniae (11. 8%). 36 strains of Gram-positive bacteria accounted for 28.3%, 11 strains of Staphylococcus epidermidis 8.7, 8 strains of Staphylococcus aureus 6.3%, Enterococcus faecium 6 strains 4.7%, fungi 7 strains 4.8%, and Candida tropicalis 4 strains 3.2%; The resistance rates of Escherichia coli to imipenem, Pseudomonas aeruginosa to amikacin and Klebsiella pneumoniae to imipenem were 100.0 and 93.8 respectively. Staphylococcus epidermidis and Staphylococcus aureus were resistant to linazolamine and vancomycin. The drug resistance rates of quinopatin and dafopentin were 100.0%. Conclusion there are many kinds of pathogenic bacteria and the rate of drug resistance is high in patients with blood tumor. It is very important to control the infection of blood by monitoring the drug resistance of the pathogens and choosing the antibiotics correctly.
【作者单位】：新疆医科大学第一附属医院血液病中心一病区;
【基金】：新疆维吾尔自治区自然科学基金资助项目(2013211A100)
【分类号】：R446.5;R733

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