广东省健康人群血液中34种金属元素含量及年龄差异分析

发布时间：2018-07-15 16:55

【摘要】：目的分析广东省不同年龄健康人群血液中34种金属元素[锂(Li)、铍(Be)、硼(B)、镁(Mg)、铝(Al)、钙(Ca)、钛(Ti)、钒(V)、铬(Cr)、锰(Mn)、铁(Fe)、钴(Co)、镍(Ni)、铜(Cu)、锌(Zn)、镓(Ga)、砷(As)、硒(Se)、铷(Rb)、锶(Sr)、锆(Zr)、钼(Mo)、银(Ag)、镉(Cd)、锡(Sn)、锑(Sb)、铯(Cs)、钡(Ba)、金(Au)、汞(Hg)、铊(Tl)、铅(Pb)、钍(Th)、铀(U)]的含量水平,为评价广东省人群体内金属元素状况和指导微量元素的补充提供依据。方法采用电感耦合等离子体质谱法(ICP-MS)对315例健康人血液进行检测,并对元素含量进行年龄差异分析。结果所测34种元素的线性关系均良好(相关系数r0.999 2),方法的检出限为0.001~49.33μg/L,相对误差为0%~11.17%,相对标准偏差为0.76%~9.54%,其中有B、Mg、Ca、Ti、Fe、Cu、Zn、Se、Rb、Sr、Mo、Ag、Cd、Cs、Au、Hg、Pb、U共18种元素含量年龄差异有统计学意义。结论 ICP-MS法可行、有效,适用于血液样品中多元素ICP-MS的同时分析。部分金属元素含量因年龄有所不同,要根据不同年龄段的需求来合理控制元素的补充。
[Abstract]:Objective to analyze 34 kinds of metal elements [Li (Li), beryllium (be), boron (B), magnesium (mg), aluminum (Al), calcium (Ca), titanium (Ti), vanadium (V), chromium (Cr), manganese (mn), iron (Fe), cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), gallium (Ga), arsenic (As), selenium (se), rubidium (RB), strontium (Sr), zirconium (Zr), molybdenum (Mo), silver in Guangdong Province. (Ag), cadmium (CD), tin (Sn), antimony (SB), cesium (Cs), barium (Ba), gold (Au), mercury (Hg), thallium (TL), lead (Pb), thorium (Th), uranium (U)], To evaluate the status of metal elements in Guangdong Province and guide the supplementation of trace elements to provide the basis. Methods Inductively coupled plasma mass spectrometry (ICP-MS) was used to detect the contents of elements in 315 healthy subjects. Results the linear relationship of the 34 elements measured was good (correlation coefficient r 0.999 2). The detection limit of the method was 0.001 渭 g / L 49.33 渭 g / L, the relative error was 0 ~ 11.17 and the relative standard deviation was 0.769.54. Among them, there were significant differences in the content of 18 elements in the co-species. Conclusion the method of ICP-MS is feasible and effective. It is suitable for simultaneous determination of multielement ICP-MS in blood samples. The content of some metal elements varies with age, so it is necessary to control the supplement of elements according to the needs of different ages.
【作者单位】：南方医科大学公共卫生学院卫生检测中心、广东省热带病研究重点实验室;中山大学测试中心;
【基金】：国家科技支撑计划项目(编号:2012BAK16B02)
【分类号】：R446.1

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