我院2011-2014年化脓性脑膜炎患者脑脊液病原菌分布及耐药性分析

发布时间：2018-08-20 08:33

【摘要】：目的:分析我院化脓性脑膜炎病原菌的分布及耐药特点,为抗菌药物的合理使用提供参考。方法:对我院2011年1月1日-2014年12月31日送检的4 255例化脓性脑膜炎住院患者脑脊液病原菌进行培养、鉴定和药敏试验。结果:共分离出834株病原菌,检出阳性率为19.6%,包括革兰氏阳性菌576株,占69.1%;革兰氏阴性菌255株,占30.6%;真菌3株,占0.4%。革兰氏阳性菌排前3位的是凝固酶阴性葡萄球菌(436株)、金黄色葡萄球菌(56株)和肠球菌属(29株);革兰氏阴性菌排前3位的是肺炎克雷伯菌(46株)、鲍曼不动杆菌(38株)和大肠埃希菌(31株)。病原菌分布科室前3位是神经外科(506株)、重症监护病房(169株)和呼吸重症科(64株)。药敏试验结果显示,葡萄球菌和肠球菌属对万古霉素、替考拉宁和米诺环素未发现耐药菌株;非发酵革兰氏阴性杆菌对米诺环素耐药率较低。结论:我院化脓性脑膜炎患者脑脊液细菌感染病原菌检出率以革兰氏阳性菌为主,各种致病菌耐药状况严重,临床应根据药敏情况合理选择抗菌药物。
[Abstract]:Objective: to analyze the distribution and drug resistance of pathogenic bacteria in suppurative meningitis in our hospital. Methods: the pathogens of cerebrospinal fluid (CSF) from 4 255 patients with suppurative meningitis from January 1, 2011 to December 31, 2014 in our hospital were cultured, identified and tested. Results: a total of 834 strains of pathogenic bacteria were isolated and the positive rate was 19.6, including 576 Gram-positive bacteria (69.1%), 255 Gram-negative bacteria (30.6%) and 3 fungi (0.445%). The top 3 Gram-positive bacteria were coagulase negative Staphylococcus (436), Staphylococcus aureus (56) and Enterococcus (29), and Gram-negative bacteria were Klebsiella pneumoniae (46) and Acinetobacter baumannii (38). E. coli (31 strains). The top 3 pathogens were neurosurgery (506), intensive care unit (169) and respiratory intensive care (64). The results of drug sensitivity test showed that Staphylococcus and Enterococcus had no resistance to vancomycin, teicoplanin and minocycline, while non-fermentative gram-negative bacilli had lower resistance to minocycline. Conclusion: the detection rate of bacterial infection in cerebrospinal fluid of patients with suppurative meningitis in our hospital is mainly Gram-positive bacteria.
【作者单位】：新疆医科大学第一附属医院药学部;新疆医科大学第二附属医院药剂科;
【分类号】：R515.2;R446.5

【相似文献】