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250例真菌性血流感染的临床特点分析

发布时间:2018-09-05 08:43
【摘要】:目的研究广东省人民医院真菌性血流感染患者的病原学及临床特点,进一步探讨真菌性血流感染的防治措施。方法回顾性分析医院250例真菌性血流感染患者的临床资料,描述其基础疾病、危险因素、转归等,并采用χ2检验,进行预后单因素分析,采用logistic回归进行预后多因素分析。结果 250例患者血培养共分离出真菌261株,真菌中最常见的是念珠菌属234株占89.7%;住院期间因各种原因死亡87例,粗病死率为34.8%;其中因真菌性血流感染死亡50例,归因病死率为20.0%;单因素分析显示中心静脉置管、机械通气、留置尿管、留置引流管、ICU治疗、使用糖皮质激素、年龄≥60与住院期间死亡相关;多因素分析中,气管插管、年龄≥60、使用糖皮质激素增加真菌性血流感染患者住院期间死亡风险。结论真菌性血流感染病原菌以念珠菌属为主,尤其是白色念珠菌,出现真菌性血流感染的患者预后差,气管插管、年龄≥60、使用糖皮质激素等增加真菌性血流感染患者住院期间死亡风险。
[Abstract]:Objective to study the etiology and clinical features of fungal blood stream infection in Guangdong Provincial people's Hospital. Methods the clinical data of 250 patients with fungal blood flow infection in hospital were analyzed retrospectively. The underlying diseases, risk factors and prognosis were described. The results were analyzed by 蠂 2 test, single factor analysis of prognosis and multivariate analysis of prognosis by logistic regression. Results 261 strains of fungi were isolated from blood culture of 250 patients, the most common fungi were 234 strains of Candida, 87 cases died from various causes, the crude mortality rate was 34.8%, and 50 cases died of fungal blood stream infection. Single factor analysis showed that central venous catheterization, mechanical ventilation, indwelling urethral catheter, indwelling drainage tube and ICU treatment, use of glucocorticoid, age 鈮,

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