某院肿瘤患者多重耐药菌感染的临床调查及耐药性分析
发布时间：2018-09-06 18:16
【摘要】：目的:调查某院肿瘤患者多重耐药菌感染特点、病原菌分布及耐药性,为临床合理应用抗菌药物,预防和控制多重耐药菌感染提供参考依据。方法:对某院2014年收治肿瘤患者的多重耐药菌感染情况进行回顾性调查分析。结果:调查期间发生肿瘤患者多重耐药菌感染492例,占医院感染的10.87%,男女比例为1.83∶1,原发肿瘤肺癌居首。其中,62.81%的患者接受过手术,45.04%的患者接受过化疗,感染部位以呼吸道、手术切口和泌尿道为主。分离出革兰阴性菌426株,革兰阳性菌66株,超广谱β-内酰胺酶(ESBLs)菌株分离率为86.62%,耐甲氧西林葡萄球菌(MRS)检出率为91.38%。提示产ESBLs肠杆菌耐药严重,仅对阿米卡星及碳青霉烯类药物显示出较好的敏感性;鲍曼不动杆菌对头孢哌酮舒巴坦敏感率最高,为29.41%。未发现耐万古霉素葡萄球菌,但检出1例耐万古霉素屎肠球菌。结论:肿瘤患者是多重耐药菌感染的高发群体,且细菌耐药性较高,临床应予以重视,加强抗菌药物合理使用,积极控制病原菌的耐药性。
[Abstract]:Objective: to investigate the characteristics, distribution and drug resistance of multidrug resistant bacteria (MDR) in cancer patients in a hospital, and to provide a reference for the rational use of antimicrobial agents and the prevention and control of MDR infection. Methods: the multidrug-resistant bacteria infection in tumor patients admitted in a hospital in 2014 was analyzed retrospectively. Results: 492 cases (10.87%) of nosocomial infection occurred multidrug resistant bacteria infection in cancer patients. The ratio of male and female was 1.83: 1. Primary tumor lung cancer was the most common. 62.81% of the patients had undergone operation and 45.04% had received chemotherapy. Respiratory tract, surgical incision and urinary tract were the main sites of infection. 426 strains of Gram-negative bacteria, 66 strains of Gram-positive bacteria, 86.62% of extended-spectrum 尾 -lactamase (ESBLs) strains were isolated, and 91.38% of methicillin-resistant staphylococcus (MRS) were detected. The results suggest that Enterobacter ESBLs is highly resistant to amikacin and carbapenem, and Acinetobacter baumannii is the most sensitive to cefoperazone sulbactam with 29.41. No vancomycin resistant staphylococcus was found, but one case of vancomycin resistant Enterococcus faecium was detected. Conclusion: tumor patients are a high incidence group of multidrug resistant bacteria infection, and bacteria resistance is high, clinical attention should be paid to strengthen the rational use of antimicrobial agents, and actively control the drug resistance of pathogens.
【作者单位】： 哈尔滨医科大学附属肿瘤医院药学部;
【分类号】：R446.5
，
本文编号：2227137
[Abstract]:Objective: to investigate the characteristics, distribution and drug resistance of multidrug resistant bacteria (MDR) in cancer patients in a hospital, and to provide a reference for the rational use of antimicrobial agents and the prevention and control of MDR infection. Methods: the multidrug-resistant bacteria infection in tumor patients admitted in a hospital in 2014 was analyzed retrospectively. Results: 492 cases (10.87%) of nosocomial infection occurred multidrug resistant bacteria infection in cancer patients. The ratio of male and female was 1.83: 1. Primary tumor lung cancer was the most common. 62.81% of the patients had undergone operation and 45.04% had received chemotherapy. Respiratory tract, surgical incision and urinary tract were the main sites of infection. 426 strains of Gram-negative bacteria, 66 strains of Gram-positive bacteria, 86.62% of extended-spectrum 尾 -lactamase (ESBLs) strains were isolated, and 91.38% of methicillin-resistant staphylococcus (MRS) were detected. The results suggest that Enterobacter ESBLs is highly resistant to amikacin and carbapenem, and Acinetobacter baumannii is the most sensitive to cefoperazone sulbactam with 29.41. No vancomycin resistant staphylococcus was found, but one case of vancomycin resistant Enterococcus faecium was detected. Conclusion: tumor patients are a high incidence group of multidrug resistant bacteria infection, and bacteria resistance is high, clinical attention should be paid to strengthen the rational use of antimicrobial agents, and actively control the drug resistance of pathogens.
【作者单位】： 哈尔滨医科大学附属肿瘤医院药学部;
【分类号】：R446.5
，
本文编号：2227137
本文链接：https://www.wllwen.com/huliyixuelunwen/2227137.html
最近更新
教材专著
