不同腹膜透析治疗模式对透析患者钙磷的代谢及PTH的影响
发布时间：2018-10-14 21:06
【摘要】：目的：探讨日间非卧床腹膜透析(DAPD)对部分患者与经典持续非卧床腹膜透析(CAPD)对患者钙磷代谢及甲状旁腺激素(PTH)的影响。方法：从新疆自治区人民医院肾病科160名行腹膜透析患者中选取符合纳入及排除标准的83例,年龄在20-80岁,平均年龄为(45.26±16.14)岁,根据不同透析方式分为两组：CAPD组：共54例,男33例,女21例；DAPD组：共29例,男16例,女13例。CAPD组每日的透析剂量为6L-8L,日间进行3次交换,每次留腹时间为5h,夜间交换1次,夜间留腹时间为9h(夜间留腹的透析液浓度为1.5%)；DAPD组透析剂量同CAPD组,但透析只在白天进行,白天交换4次,每次交换时间为4h,夜间排空腹腔；观察指标：病人的一般资料、原发病、血红蛋白(Hb)、血钙(Ca)、血磷(P)、甲状旁腺激素(PTH)、血浆白蛋白(ALB)、血肌酐(Scr)、甘油三酯(TG)、尿素氮(BUN)、超滤量以及残余肾功能。实验数据以x±S表示,两组间比较采用t检验,P0.05表示差异有统计学意义。结果：两组在一般资料比较中差异无统计学意义(P0.05)；两组治疗一年后,DAPD组Hb、ALB、Scr、Ca、P、PTH、4h净超滤量改善优于CAPD组,并有统计学意义(P0.05)；两组透前残余肾功能无差异,但治疗一年后DAPD组残余肾功能优于CAPD组,并有统计学意义(P0.05)。结论：行DAPD治疗在改善钙磷代谢及PTH等状况优于CAPD治疗,并能更好的保护残余肾功能。
[Abstract]:Objective: to investigate the effects of (DAPD) on calcium and phosphorus metabolism and parathyroid hormone (PTH) in some patients and in patients with classic continuous ambulatory peritoneal dialysis (CAPD). Methods: 83 peritoneal dialysis patients, aged 20-80 years, with an average age of (45.26 卤16.14) years, were selected from 160 patients undergoing peritoneal dialysis in Renal Department of Xinjiang Autonomous region people's Hospital. According to different dialysis methods, they were divided into two groups: CAPD group: 54 cases. There were 33 males and 21 females in DAPD group: 29 patients, 16 males and 13 females. The dialytic dose of CAPD group was 6L-8L daily. Nocturnal peritoneal retention time was 9h (the concentration of nocturnal peritoneal dialysate was 1.5%); DAPD group dialysis dose was the same as that of CAPD group, but dialysis was only carried out during the day, the exchange time was 4 hours during the day, each time was 4 hours, the abdominal cavity was emptied at night. Primary, hemoglobin, (Hb), serum calcium, (Ca), serum phosphorus, (P), parathyroid hormone, (PTH), plasma albumin, serum creatinine, (Scr), triglyceride, (TG), urea nitrogen, (BUN), ultrafiltration and residual renal function. The experimental data were expressed as x 卤S, and the difference between the two groups was statistically significant. Results: there was no significant difference in general data between the two groups (P0.05); after one year of treatment, the improvement of Hb,ALB,Scr,Ca,P,PTH,4h net ultrafiltration in DAPD group was better than that in CAPD group (P0.05); there was no difference in residual renal function before dialysis between the two groups. But one year after treatment, the residual renal function in DAPD group was better than that in CAPD group, and there was statistical significance (P0.05). Conclusion: DAPD is superior to CAPD in improving calcium and phosphorus metabolism and PTH, and can better protect residual renal function.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R459.5
，
本文编号：2271646
[Abstract]:Objective: to investigate the effects of (DAPD) on calcium and phosphorus metabolism and parathyroid hormone (PTH) in some patients and in patients with classic continuous ambulatory peritoneal dialysis (CAPD). Methods: 83 peritoneal dialysis patients, aged 20-80 years, with an average age of (45.26 卤16.14) years, were selected from 160 patients undergoing peritoneal dialysis in Renal Department of Xinjiang Autonomous region people's Hospital. According to different dialysis methods, they were divided into two groups: CAPD group: 54 cases. There were 33 males and 21 females in DAPD group: 29 patients, 16 males and 13 females. The dialytic dose of CAPD group was 6L-8L daily. Nocturnal peritoneal retention time was 9h (the concentration of nocturnal peritoneal dialysate was 1.5%); DAPD group dialysis dose was the same as that of CAPD group, but dialysis was only carried out during the day, the exchange time was 4 hours during the day, each time was 4 hours, the abdominal cavity was emptied at night. Primary, hemoglobin, (Hb), serum calcium, (Ca), serum phosphorus, (P), parathyroid hormone, (PTH), plasma albumin, serum creatinine, (Scr), triglyceride, (TG), urea nitrogen, (BUN), ultrafiltration and residual renal function. The experimental data were expressed as x 卤S, and the difference between the two groups was statistically significant. Results: there was no significant difference in general data between the two groups (P0.05); after one year of treatment, the improvement of Hb,ALB,Scr,Ca,P,PTH,4h net ultrafiltration in DAPD group was better than that in CAPD group (P0.05); there was no difference in residual renal function before dialysis between the two groups. But one year after treatment, the residual renal function in DAPD group was better than that in CAPD group, and there was statistical significance (P0.05). Conclusion: DAPD is superior to CAPD in improving calcium and phosphorus metabolism and PTH, and can better protect residual renal function.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R459.5
，
本文编号：2271646
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