2014年上海市医务人员麻疹、风疹及流行性腮腺炎血清学特征研究

发布时间：2018-10-30 15:11

【摘要】：目的了解上海市医务人员(Healthcare Workers,HCWs)麻疹、风疹及流行性腮腺炎(流腮)的抗体水平,为制定针对性的免疫策略提供依据。方法采集全市4家一级医院、3家二级医院、2家三级医院的HCWs的全血标本700份,检测血清麻疹、风疹及流腮Ig G抗体。结果 HCWs麻疹抗体阳性率为97.00%,几何平均浓度(Geometric Mean Concentration,GMC)为946.82 mIU/ml,不同年龄组、户籍类型、医院级别、科室类型、免疫史、患病史HCWs间麻疹抗体阳性率无统计学差异。风疹抗体阳性率为81.29%,GMC为39.16 IU/ml。流腮抗体阳性率为83.43%,GMC为225.03 IU/ml。Logistic回归结果显示,20~39岁HCWs风疹抗体阳性率高于40岁及以上HCWs;一级医院HCWs风疹抗体阳性率高于二、三级医院HCWs。50岁及以上HCWs流腮抗体水平高于20~49岁HCWs;一、二级医院HCWs流腮抗体水平高于三级医院HCWs。结论 HCWs对麻疹普遍免疫,但对既往无明确免疫史的HCWs,尤其是新进职工、护工、医学院研究生等对象开展含麻疹成分疫苗查漏补种仍有必要。同时加强对二、三级医院HCWs的宣传动员,进一步提高接种率,通过接种麻疹风疹或麻腮风联合减毒活疫苗控制HCWs中风疹和流腮的发病。
[Abstract]:Objective to investigate the antibody levels of measles, rubella and mumps (gills) in medical workers (Healthcare Workers,HCWs) in Shanghai. Methods 700 whole blood samples of HCWs were collected from 4 first class hospitals, 3 second class hospitals and 2 third class hospitals. The serum measles, rubella and Ig G antibodies were detected. Results the positive rate of HCWs measles antibody was 97.00 and the geometric mean concentration (Geometric Mean Concentration,GMC) was 946.82 mIU/ml, in different age groups, household registration type, hospital grade, department type, immune history. There was no significant difference in measles antibody positive rate between HCWs patients. The positive rate of rubella antibody was 81.29 and 39.16 IU/ml.. The positive rate of HCWs rubella antibody in 20- 39 years old was higher than that of 40 years old and over HCWs;. The positive rate of GMC was 225.03 IU/ml.Logistic. The results showed that the positive rate of HCWs rubella antibody was higher at 20 ~ 39 years old than that of 40 years old. The positive rate of HCWs rubella antibody in the first class hospital was higher than that in the second grade hospital. The level of HCWs gills antibody in the third class hospital was higher than that in the third class hospital, and the level of HCWs antibody in the second class hospital was higher than that in the third class hospital HCWs.. Conclusion HCWs is widely immunized against measles, but it is still necessary for HCWs, especially for new workers, nursing workers and graduate students of medical school, to detect measles vaccine. At the same time, we should strengthen the propaganda and mobilization of HCWs in the second and third level hospitals, further improve the vaccination rate, and control the incidence of rubella and gills in HCWs by inoculating measles rubella or leprosy with live attenuated vaccine.
【作者单位】：上海市疾病预防控制中心;复旦大学公共卫生学院;
【基金】：上海市第四轮公共卫生三年行动计划重点学科建设项目-传染病与卫生微生物学(编号:15GWZK0101)
【分类号】：R446.6

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