老年待输血患者Rh系统表型分型和不规则抗体检测及临床意义

发布时间：2018-11-09 11:40

【摘要】：目的:了解老年待输血患者Rh系统表型分型,分析其不规则抗体阳性率,为老年患者临床输血安全性提供依据。方法:选择老年待输血患者587例,采用微柱凝胶法对患者进行Rh系统抗原检测及不规则抗体鉴定。结果:587例患者中测得Rh血型表现型共7种,均为RhD阳性,Rh血型表现型的频率由高到低分别为CCDee占38.7%(227/587)、CcDEe占34.7%(204/587)、CcDee占12.4%(73/587)、ccDEE占8.7%(51/587)、ccDEe占4.6%(27/587)、CCDEe占0.7%(4/587)和ccDee占0.2%(1/587)。587例患者中检出不规则抗体6例,阳性率为1.02%,分别为4例抗-E(占66.67%)、1例抗-c(占16.67%)、1例抗-M(占16.67%);有输血史或妊娠史患者不规则抗体阳性率[2.65%(5/189)]高于无输血史及妊娠史者[0.25%(1/398)](χ~2=5.11,P0.05);不同民族老年患者不规则抗体阳性率比较差异无统计学意义(χ~2=0.10,P0.05)。结论:Rh系统抗体是老年待输血患者中最主要的不规则抗体,应对有输血史或妊娠史的老年患者进行Rh表型分型检测及不规则抗体筛查鉴定,以确保老年患者的输血安全。
[Abstract]:Objective: to study the phenotypic typing of Rh system in elderly patients with blood transfusion, and to analyze the positive rate of irregular antibodies in order to provide evidence for clinical transfusion safety of elderly patients. Methods: Rh system antigen and irregular antibody were detected by microcolumn gel method in 587 elderly patients. Results: there were 7 Rh phenotypes detected in 587 patients, all of which were RhD positive. The frequency of Rh phenotypes was 38.7% (22.7 / 587), CcDEe, 20.4 / 587) from high to low, respectively. CcDee accounted for 12.4% (73 / 587), ccDEE, 8.7%) (51 / 587), ccDEe, 4.6% (27 / 587), CCDEe, 0.7%, 4 / 587) and ccDee, 0.2% (1 / 587). Irregular antibodies were detected in 6 of 587 patients. The positive rate of anti-E was 1.02% in 4 cases (66.67%), anti-c in 1 case (16.67%) and anti-M in 1 case (16.67%). The positive rate of irregular antibody in patients with history of blood transfusion or pregnancy [2.65% (5 / 189)] was higher than that of patients without history of blood transfusion and pregnancy (0.25%) (1 / 398) (蠂 ~ 25.11P 0.05). There was no significant difference in the positive rate of irregular antibody between the elderly patients of different nationalities (蠂 ~ 2 ~ 0.10% P 0.05). Conclusion: Rh system antibody is the most important irregular antibody in elderly patients with blood transfusion. The Rh phenotypic typing and irregular antibody screening should be carried out in elderly patients with history of blood transfusion or pregnancy in order to ensure the safety of blood transfusion in elderly patients.
【作者单位】：吉林大学第一医院输血科;吉林大学中日联谊医院皮肤科;延边大学附属医院输血科;吉林省肿瘤医院输血科;
【基金】：吉林省科技厅自然科学基金资助课题(20150101143)
【分类号】：R457.1

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