体检人群尿微量白蛋白肌酐比的临床意义
发布时间：2018-11-18 15:32
【摘要】：目的探讨尿微量白蛋白肌酐比(mALB/Cr)在体检人群中的分布特征及其与相关代谢指标的关系。方法收集2013年11月至2014年10月我院体检中心体检项目包括尿mALB/Cr的4 184例体检者的体质量指数(BMI)、收缩压(SBP)、舒张压(DBP)、腰围、臀围、腰臀比(WHR)、尿mALB/Cr及血糖(GLU)、血脂〔总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)〕、肾功能〔尿素氮(BUN)、血肌酐(SCr)、尿酸(UA)、血清胱抑素C(Cys-C)、估计肾小球滤过率(eGFR)〕、同型半胱氨酸(Hcy)等结果,分析尿mALB/Cr在体检人群中的分布特征,尿mALB/Cr与相关代谢指标的关系,微量白蛋白尿(MAU)发生的独立危险因素。结果 14 184例纳入分析的体检者的尿mALB/Cr中位数(四分位间距)为5.7(3.1~11.8)mg/g,其中男性5.4(3.0~11.3)mg/g,女性6.3(3.6~13.2)mg/g,男女性别间差异有统计学意义(P0.05)。2体检者尿mALB/Cr总阳性率(mALB/Cr≥30mg/g为阳性)为10.95%,其中男性10.96%,女性10.90%,男女性别间差异无统计学意义(P0.05)。3尿mALB/Cr中位数与阳性率均随着年龄增加而升高。4按mALB/Cr30mg/g、30~300mg/g、300mg/g分为正常、微量白蛋白尿、显性白蛋白尿3组,3组体检者间的年龄、BMI、SBP、DBP、腰围、WHR、GLU、HDL-C、TG、SCr、BUN、UA、eGFR、Cys-CR的差异均有统计学意义(P0.05)。5Logistic多元回归分析显示年龄、SBP、WHR、GLU、TG的增加及eGFR的降低是微量白蛋白尿发生的独立危险因素。结论体检人群中尿mALB/Cr异常率较高,年龄、血压、血糖、血脂升高及肾功能下降均可增加微量白蛋白尿发生的风险,应加强对高代谢综合征及中老年人群的尿mALB/Cr检测。
[Abstract]:Objective to investigate the distribution of urinary albumin creatinine ratio (mALB/Cr) and its relationship with related metabolic indexes. Methods from November 2013 to October 2014, the body mass index (BMI), (SBP), diastolic blood pressure (DBP), waist circumference, hip circumference and waist-to-hip ratio (WHR),) of 4,184 subjects with urinary mALB/Cr were collected. Urine mALB/Cr and blood glucose (GLU), lipids (total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) low density lipoprotein cholesterol (LDL-C),) renal function (urea nitrogen (BUN),) The serum levels of cystatin C (Cys-C) and glomerular filtration rate (eGFR),) homocysteine (Hcy) were estimated by serum creatinine (SCr), uric acid (SCr),) (UA), and the distribution characteristics of urinary mALB/Cr in healthy population were analyzed. The relationship between urinary mALB/Cr and related metabolic indexes, and the independent risk factors of microalbuminuria (MAU). Results the median urinary mALB/Cr (quartile spacing) of 14,184 subjects in the analysis was 5.7 (3.1 / 11.8) mg/g, including 5.4 (3.011.3) mg/g, / female 6.3 (3.6 / 13.2) mg/g, for males. The total positive rate of urinary mALB/Cr (mALB/Cr 鈮，
本文编号：2340427
[Abstract]:Objective to investigate the distribution of urinary albumin creatinine ratio (mALB/Cr) and its relationship with related metabolic indexes. Methods from November 2013 to October 2014, the body mass index (BMI), (SBP), diastolic blood pressure (DBP), waist circumference, hip circumference and waist-to-hip ratio (WHR),) of 4,184 subjects with urinary mALB/Cr were collected. Urine mALB/Cr and blood glucose (GLU), lipids (total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) low density lipoprotein cholesterol (LDL-C),) renal function (urea nitrogen (BUN),) The serum levels of cystatin C (Cys-C) and glomerular filtration rate (eGFR),) homocysteine (Hcy) were estimated by serum creatinine (SCr), uric acid (SCr),) (UA), and the distribution characteristics of urinary mALB/Cr in healthy population were analyzed. The relationship between urinary mALB/Cr and related metabolic indexes, and the independent risk factors of microalbuminuria (MAU). Results the median urinary mALB/Cr (quartile spacing) of 14,184 subjects in the analysis was 5.7 (3.1 / 11.8) mg/g, including 5.4 (3.011.3) mg/g, / female 6.3 (3.6 / 13.2) mg/g, for males. The total positive rate of urinary mALB/Cr (mALB/Cr 鈮，
本文编号：2340427
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