血清白细胞介素-8与C-反应蛋白对新生儿细菌感染诊治的应用研究
发布时间：2018-11-25 16:24
【摘要】：目的探讨血清白细胞介素-8(IL-8)与C-反应蛋白(CRP)测定对新生儿细菌感染诊治效果,从而提高新生儿细菌感染检测和治疗的科学性。方法选择2013年6月-2014年11月医院出生的100例新生儿为研究对象,将临床确诊细菌感染新生儿52例为观察组,临床疑似细菌感染新生儿48例为对照组;对两组新生儿进行血常规、血培养和IL-8+CRP检测,并对其给予抗菌药物临床治疗,视实际病情待新生儿痊愈后再次进行上述指标检测,观察两组新生儿检测指标阴性与阳性例数和IL-8联合CRP预测新生儿感染情况,并比较新生儿治疗前后IL-8、CRP水平差异;采用SPSS13.0软件对数据进行统计分析。结果观察组在血常规、血培养和IL-8+CRP检测阳性例数均高于对照组,其中IL-8+CRP检测阳性例数最多,高于对照组26例,差异有统计学意义(P0.05);发现采用IL-8联合CRP预测新生儿感染阴性预测率为98.93%,预测率明显高于单一采用IL-8或CRP,差异有统计学意义(P0.05);两组新生儿治疗后IL-8、CRP水平较治疗前均明显下降,降为正常水平,差异有统计学意义(P0.05)。结论综合运用血清IL-8联合CRP测定在新生儿细菌感染检测中能够提高检测准确度和精度,避免误诊、漏诊,且抗菌药物使用以IL-8≥80ng/L或CRP≥10mg/L临界值最佳。
[Abstract]:Objective to investigate the effect of serum interleukin-8 (IL-8) and C-reactive protein (CRP) in the diagnosis and treatment of neonatal bacterial infection, so as to improve the scientific nature of the detection and treatment of neonatal bacterial infection. Methods 100 newborns born in hospital from June 2013 to November 2014 were selected as study objects. 52 newborns with clinically confirmed bacterial infection were selected as observation group and 48 neonates with suspected bacterial infection as control group. Blood routine test, blood culture and IL-8 CRP test were carried out in the two groups of newborns, and they were treated with antimicrobial drugs, and the above indexes were tested again after the newborns were cured according to the actual condition. The neonatal infection was predicted by IL-8 combined with CRP, and the difference of IL-8,CRP level before and after treatment was compared between the two groups. The data were analyzed by SPSS13.0 software. Results the positive cases of blood routine, blood culture and IL-8 CRP detection in the observation group were higher than those in the control group, among which the IL-8 CRP positive cases were the most, higher than the control group in 26 cases, the difference was statistically significant (P0.05). It was found that the negative predictive rate of neonatal infection using IL-8 combined with CRP was 98.93, and the predictive rate was significantly higher than that using IL-8 or CRP, alone (P0.05). The level of IL-8,CRP in the two groups after treatment was significantly lower than that before treatment, and decreased to the normal level, the difference was statistically significant (P0.05). Conclusion the combined use of serum IL-8 and CRP in the detection of neonatal bacterial infection can improve the accuracy and accuracy of detection, avoid misdiagnosis and missed diagnosis, and the critical value of IL-8 鈮，
本文编号：2356741
[Abstract]:Objective to investigate the effect of serum interleukin-8 (IL-8) and C-reactive protein (CRP) in the diagnosis and treatment of neonatal bacterial infection, so as to improve the scientific nature of the detection and treatment of neonatal bacterial infection. Methods 100 newborns born in hospital from June 2013 to November 2014 were selected as study objects. 52 newborns with clinically confirmed bacterial infection were selected as observation group and 48 neonates with suspected bacterial infection as control group. Blood routine test, blood culture and IL-8 CRP test were carried out in the two groups of newborns, and they were treated with antimicrobial drugs, and the above indexes were tested again after the newborns were cured according to the actual condition. The neonatal infection was predicted by IL-8 combined with CRP, and the difference of IL-8,CRP level before and after treatment was compared between the two groups. The data were analyzed by SPSS13.0 software. Results the positive cases of blood routine, blood culture and IL-8 CRP detection in the observation group were higher than those in the control group, among which the IL-8 CRP positive cases were the most, higher than the control group in 26 cases, the difference was statistically significant (P0.05). It was found that the negative predictive rate of neonatal infection using IL-8 combined with CRP was 98.93, and the predictive rate was significantly higher than that using IL-8 or CRP, alone (P0.05). The level of IL-8,CRP in the two groups after treatment was significantly lower than that before treatment, and decreased to the normal level, the difference was statistically significant (P0.05). Conclusion the combined use of serum IL-8 and CRP in the detection of neonatal bacterial infection can improve the accuracy and accuracy of detection, avoid misdiagnosis and missed diagnosis, and the critical value of IL-8 鈮，
本文编号：2356741
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