局部晚期非小细胞肺癌根治性放疗患者感染病原菌分布与危险因素分析

发布时间：2018-12-06 22:04

【摘要】：目的探讨接受根治性放疗的局部晚期非小细胞肺癌患者发生医院感染病原菌分布及危险因素分析,为降低医院感染率提供依据。方法回顾性分析2012年5月-2014年6月70例局部晚期非小细胞肺癌患者的临床资料,分析其感染病原菌分布及相关危险因素;采用SPSS19.0软件进行统计分析。结果 70例局部晚期非小细胞肺癌患者发生医院感染31例,感染率为44.29%,感染部位以呼吸道、胃肠道、泌尿系统为主,分别占45.16%、19.36%、16.13%;共检出病原菌40株,其中革兰阴性菌、革兰阳性菌、真菌分别占52.50%、42.50%、5.00%;革兰阴性菌以大肠埃希菌、铜绿假单胞菌为主,分别占20.00%、15.00%;革兰阳性菌则以金黄色葡萄球菌、表皮葡萄球菌为主,分别占15.00%、12.50%;单因素分析表明,年龄、住院时间、血红蛋白含量、白蛋白含量、合并其他疾病是局部晚期非小细胞肺癌患者发生医院感染的危险因素(P0.05),logistic回归分析发现,年龄、住院时间、血红蛋白含量、白蛋白含量、合并其他疾病等是发生医院感染的独立危险因素(P0.05)。结论局部晚期非小细胞肺癌患者发生医院感染相关危险因素较多,应采取相应措施,加强感染管理及积极治疗患者基础疾病,以降低医院感染率。
[Abstract]:Objective to investigate the distribution and risk factors of nosocomial infection in patients with locally advanced non-small cell lung cancer (NSCLC) receiving radical radiotherapy, and to provide evidence for reducing nosocomial infection rate. Methods the clinical data of 70 patients with locally advanced non-small cell lung cancer (NSCLC) from May 2012 to June 2014 were analyzed retrospectively and the distribution of pathogenic bacteria and related risk factors were analyzed by SPSS19.0 software. Results there were 31 cases of nosocomial infection in 70 patients with local advanced non-small cell lung cancer, the infection rate was 44.29. Respiratory tract, gastrointestinal tract and urinary system were the main sites of infection, accounting for 45.16% 19.36% and 16.13% respectively. A total of 40 strains of pathogenic bacteria were identified, of which Gram-negative bacteria, Gram-positive bacteria and fungi accounted for 52.50 and 42.50 respectively, Gram-negative bacteria were mainly Escherichia coli and Pseudomonas aeruginosa, accounting for 20.00 and 15.00, respectively. Gram-positive bacteria were mainly Staphylococcus aureus and Staphylococcus epidermidis, accounting for 15.00% and 12.50% respectively. Univariate analysis showed that age, hospitalization time, hemoglobin content, albumin content, and other diseases were the risk factors of nosocomial infection in patients with locally advanced non-small cell lung cancer (P0.05), logistic regression analysis, age, and age). Hospital stay, hemoglobin content, albumin content and other diseases were independent risk factors for nosocomial infection (P0.05). Conclusion there are many risk factors associated with nosocomial infection in patients with locally advanced non-small cell lung cancer (NSCLC), and the corresponding measures should be taken to strengthen infection management and actively treat patients with basic diseases in order to reduce the nosocomial infection rate.
【作者单位】：台州市中心医院放疗科;宁波市第一医院肿瘤放疗科;
【基金】：国家自然科学基金资助项目(30800347)
【分类号】：R446.5

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