磁刺激不同穴位脑功能网络研究
发布时间：2018-12-11 08:29
【摘要】：磁刺激技术作为一种具有众多显著优势的诊断与治疗技术,在神经功能的调控以及疾病治疗方面具有无以比拟的优势。2000多年来,传统中医学一直被人们视为治疗多种疾病的有效方法,将磁刺激技术与针灸技术结合而产生的穴位磁刺激技术,在为磁刺激技术的推广应用赋予新内容的同时,也进一步揭开了传统中医学治疗疾病的神秘面纱。穴位磁刺激技术可以等效为在外部对大脑神经系统施加的一种刺激手段,该技术对研究大脑的调控机制以及许多疾病的康复治疗有重大意义。脑科学中复杂网络理论的飞速发展为磁刺激穴位的研究提供了新思路,本文采用磁刺激技术刺激人体外关穴、合谷穴、神门穴,分别提取磁刺激前和磁刺激时的脑电信号并对其进行分析。主要内容如下:1、磁刺激外关、合谷、神门穴关联特性以及脑连接的变化情况:研究发现磁刺激外关穴、合谷穴、神门穴时被试组间各通道节点之间关联特性的变化以及与邻接矩阵所对应的大脑皮层网络连接图的变化存在显著差异;2、磁刺激外关、合谷、神门穴全局属性脑网络测度分析:研究磁刺激对脑功能网络全局属性网络指标的影响以及三组被试网络测度随阈值的变化情况。研究结果发现各组被试的脑网络测度变化趋势具有很大差异性,体现在磁刺激不同的穴位时即使相同的网络测度其变化规律不一致,针对同一穴位相同测度在不同的阈值区间上变化情况也是不一致的。这一方面揭示了磁刺激不同穴位会结合穴位特异性从不同的侧面去改善脑功能,另一方面也体现阈值选取在脑网络研究中的重要性;3、磁刺激外关、合谷、神门穴局部属性脑网络测度以及小世界属性分析:研究结果发现磁刺激不同穴位局部属性网络指标在相同以及不同脑功能区上变化差异较大;本文构建的脑网络均属于小世界网络范畴。本文的研究工作从复杂网络角度探索磁刺激不同穴位时大脑功能网络连接的变化规律以及对应的脑功能网络的拓扑结构属性,从而探索磁刺激穴位对大脑神经调节的作用效应,为磁刺激疗法应用于临床提供一定的参考价值。
[Abstract]:As a kind of diagnosis and treatment technology with many remarkable advantages, magnetic stimulation technology has unparalleled advantages in the regulation of nerve function and the treatment of diseases for more than 2000 years. Traditional Chinese medicine has always been regarded as an effective method for the treatment of many diseases. The magnetic stimulation at acupoints produced by combining magnetic stimulation and acupuncture technology has given new content to the popularization and application of magnetic stimulation. It also uncovers the mystery of traditional Chinese medicine in treating diseases. The technique of acupoint magnetic stimulation can be equivalent to a kind of stimulation applied externally to the neural system of the brain, which is of great significance to the study of the regulatory mechanism of the brain and the rehabilitation treatment of many diseases. The rapid development of complex network theory in brain science provides a new idea for the study of magnetic stimulation acupoints. The EEG signals before and after magnetic stimulation were extracted and analyzed respectively. The main contents are as follows: 1. The correlation characteristics of magnetic stimulation, Hegu and Shenmen acupoints and the changes of brain junctions: the study found that magnetic stimulation of Waiguan acupoints, Hegu acupoints, At Shenmen acupoint, there were significant differences in the correlation characteristics of each channel node and the cortical network connection map corresponding to the adjoining matrix. 2. The global attribute brain network measure analysis of magnetic stimulation, Hegu and Shenmen points: the influence of magnetic stimulation on the global attribute network index of brain functional network and the changes of three groups of network measures with threshold were studied. The results showed that the change trend of brain network measurement in each group was very different, which was reflected in different points of magnetic stimulation, even if the same network measure its change law was not consistent. The variation of the same measure of the same acupoint in different threshold ranges is also inconsistent. On the one hand, it reveals that different acupoints of magnetic stimulation can improve brain function from different sides in combination with acupoint specificity, on the other hand, it also shows the importance of threshold selection in the study of brain network. 3. The measurement of local properties of brain network and the analysis of small-world attribute of magnetic stimulation. The results showed that the local attribute network indexes of different acupoints of magnetic stimulation varied greatly in the same and different brain functional areas. The brain network constructed in this paper belongs to the category of small world network. From the point of view of complex network, this paper explores the change rule of brain functional network connection and the topological properties of corresponding brain functional network under different acupoints of magnetic stimulation, so as to explore the effect of magnetic stimulation acupoint on the regulation of cerebral nerve. It provides some reference value for the application of magnetic stimulation therapy in clinic.
【学位授予单位】：河北工业大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R454.1
本文编号：2372230
[Abstract]:As a kind of diagnosis and treatment technology with many remarkable advantages, magnetic stimulation technology has unparalleled advantages in the regulation of nerve function and the treatment of diseases for more than 2000 years. Traditional Chinese medicine has always been regarded as an effective method for the treatment of many diseases. The magnetic stimulation at acupoints produced by combining magnetic stimulation and acupuncture technology has given new content to the popularization and application of magnetic stimulation. It also uncovers the mystery of traditional Chinese medicine in treating diseases. The technique of acupoint magnetic stimulation can be equivalent to a kind of stimulation applied externally to the neural system of the brain, which is of great significance to the study of the regulatory mechanism of the brain and the rehabilitation treatment of many diseases. The rapid development of complex network theory in brain science provides a new idea for the study of magnetic stimulation acupoints. The EEG signals before and after magnetic stimulation were extracted and analyzed respectively. The main contents are as follows: 1. The correlation characteristics of magnetic stimulation, Hegu and Shenmen acupoints and the changes of brain junctions: the study found that magnetic stimulation of Waiguan acupoints, Hegu acupoints, At Shenmen acupoint, there were significant differences in the correlation characteristics of each channel node and the cortical network connection map corresponding to the adjoining matrix. 2. The global attribute brain network measure analysis of magnetic stimulation, Hegu and Shenmen points: the influence of magnetic stimulation on the global attribute network index of brain functional network and the changes of three groups of network measures with threshold were studied. The results showed that the change trend of brain network measurement in each group was very different, which was reflected in different points of magnetic stimulation, even if the same network measure its change law was not consistent. The variation of the same measure of the same acupoint in different threshold ranges is also inconsistent. On the one hand, it reveals that different acupoints of magnetic stimulation can improve brain function from different sides in combination with acupoint specificity, on the other hand, it also shows the importance of threshold selection in the study of brain network. 3. The measurement of local properties of brain network and the analysis of small-world attribute of magnetic stimulation. The results showed that the local attribute network indexes of different acupoints of magnetic stimulation varied greatly in the same and different brain functional areas. The brain network constructed in this paper belongs to the category of small world network. From the point of view of complex network, this paper explores the change rule of brain functional network connection and the topological properties of corresponding brain functional network under different acupoints of magnetic stimulation, so as to explore the effect of magnetic stimulation acupoint on the regulation of cerebral nerve. It provides some reference value for the application of magnetic stimulation therapy in clinic.
【学位授予单位】：河北工业大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R454.1
【参考文献】
相关期刊论文 前1条
1 邱迎伟;江桂华;苏欢欢;马晓芬;李黎明;田军章;张雪林;;海洛因成瘾患者眶额叶皮层功能连接异常与决策能力缺失的关系[J];南方医科大学学报;2013年08期
，本文编号：2372230
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