焦化厂工人尿中多环芳烃代谢物浓度的影响因素

发布时间：2019-01-21 10:13

【摘要】：[目的]以尿中多环芳烃代谢产物2-羟基萘(2-NAP)、2-羟基芴(2-FLU)、9-羟基菲(9-PHE)和1-羟基芘(1-OHP)作为生物标志,评价焦化厂工人体内多环芳烃(PAHs)暴露水平,探讨4种PAHs代谢物浓度的影响因素。[方法]对某焦化厂焦炉工437人(接触组)及非焦炉工167人(对照组)进行问卷调查,高效液相色谱-荧光检测法测定两组工人晨尿中4种多环芳烃代谢物水平。[结果]接触组尿中羟基代谢产物2-NAP、2-FLU、9-PHE和1-OHP浓度的中位数[分别为0.725、0.300、0.092、0.059μg/mmo L(以Cr计)]均显著高于对照组[分别为0.615、0.197、0.065、0.040μg/mmo L(以Cr计)](P0.01);逐步logistic回归分析显示吸烟量每增加一个等级,致2-NAP发生高浓度的可能性增加了3.393倍;接触组的代谢物2-NAP、2-FLU、9-PHE和1-OHP发生高浓度的可能性分别是对照组的1.665、3.399、2.185和2.905倍。[结论]影响人群尿中多环芳烃代谢物浓度的主要因素是工种和吸烟,其中2-FLU与1-OHP是焦炉工职业暴露敏感的生物标志,而2-NAP是吸烟暴露敏感的生物标志。
[Abstract]:[objective] to use 2-hydroxy-naphthalene (2-NAP), 2-hydroxy-fluorene (2-FLU), 9-hydroxyphenanthrene (9-PHE) and 1-hydroxypyrene (1-OHP) as biomarkers of polycyclic aromatic hydrocarbons (PAHs) metabolites in urine. To evaluate the exposure level of polycyclic aromatic hydrocarbons (PAHs) (PAHs) in coking plant workers and to explore the factors influencing the concentration of four PAHs metabolites. [methods] A questionnaire survey was conducted among 437 coke oven workers (contact group) and 167 non-coke oven workers (control group) in a coking plant. The levels of four polycyclic aromatic hydrocarbons (PAHs) metabolites in morning urine of two groups of workers were determined by high performance liquid chromatography-fluorescence detection. [results] the urinary hydroxyl metabolites 2-NAPN, 2-FLU, were found in the exposed group. The median concentrations of 9-PHE and 1-OHP [0.725 ~ 0.300 渭 g/mmo / L (in Cr)] were significantly higher than those in the control group [0.615 ~ 0.197 0.197 ~ 0.065 ~ 0.040 渭 g/mmo / L (Cr)] (P0.01). Stepwise logistic regression analysis showed that the probability of high concentration of 2-NAP increased by 3.393 times with the increase of smoking volume by one grade. The risk of high concentration of 2-NAPP 2-FLUE 9-PHE and 1-OHP in the exposed group was 2.905 times higher than that in the control group (1.665U 3.399C 2.185 and 2.905 times respectively). [conclusion] the main factors affecting the concentration of PAHs in urine are type of work and smoking. 2-FLU and 1-OHP are sensitive biomarkers for occupational exposure of coke oven workers, and 2-NAP is sensitive biomarkers for exposure to smoking.
【作者单位】：山西医科大学公共卫生学院劳动卫生学教研室;
【基金】：国家自然科学基金项目(编号:81273041,30901180)
【分类号】：R446.12;R13

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