输注红细胞对恶性血液病患者T淋巴细胞亚群的影响

发布时间：2019-02-12 11:46

【摘要】：目的:探讨输注红细胞对恶性血液病患者T淋巴细胞亚群的影响。方法:山西医科大学第二医院2013年9月至2014年9月在血液内科住院的明确诊断为恶性血液病并需要输注红细胞的患者共144例,所有患者均符合临床输血指征(血红蛋白的含量均低于70 g/L)。所有患者在化疗休息期间和检测期间均未服用免疫调节药物。用流式细胞术分别检测患者在输注红细胞前及输注后1月内的T淋巴细胞亚群,观察输注红细胞前后恶性血液病患者T淋巴细胞亚群的变化。结果:85例恶性血液病患者输注红细胞后10 d内,在外周血中的CD3~+、CD3~+CD4~+和CD3~+CD8~+均升高(P0.05);59例恶性血液病患者输注红细胞后10-30 d内CD3~+CD8~+增加,CD3~+CD4~+、Th/Ts下降(P0.05)。AML、ALL、MDS、MM患者输注红细胞后的T细胞亚群值有不同的变化。结论:输注红细胞对恶性血液病患者的T淋巴细胞亚群有影响。输注红细胞初期,机体细胞免疫功能可略增强或不变,随着免疫应答进行,抑制细胞占优势,细胞免疫功能受到抑制。
[Abstract]:Objective: to investigate the effect of erythrocyte infusion on T lymphocyte subsets in patients with malignant hematopathy. Methods: from September 2013 to September 2014, 144 patients with malignant hematological diseases who were hospitalized in Department of Hematology, second Hospital of Shanxi Medical University, needed to be infused with red blood cells. All patients were in accordance with the clinical indications of blood transfusion (hemoglobin levels were lower than 70 g / L). All patients did not take immunoregulatory drugs during the rest of chemotherapy and during testing. The T lymphocyte subsets before and after erythrocyte transfusion were detected by flow cytometry, and the changes of T lymphocyte subsets in patients with hematologic malignancy before and after erythrocyte transfusion were observed. Results: the levels of CD3~, CD3~ CD4~ and CD3~ CD8~ in peripheral blood of 85 patients with malignant hematologic diseases increased significantly within 10 days after erythrocyte transfusion (P0.05). In 59 patients with malignant hematologic diseases, CD3~ CD8~ increased and CD3~ CD4~ and Th/Ts decreased within 10-30 days after erythrocyte transfusion (P0.05). The T cell subsets of AML,ALL,MDS,MM patients changed differently after erythrocyte transfusion. Conclusion: red blood cell transfusion has an effect on T lymphocyte subsets in patients with malignant hematologic diseases. At the beginning of erythrocyte transfusion, the cellular immune function was slightly enhanced or unchanged. With the immune response, the inhibition of cells was dominant, and the cellular immune function was inhibited.
【作者单位】：清华大学附属北京市垂杨柳医院血液科;
【分类号】：R457.1;R733

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