血清生长分化因子-15与N末端B型利钠肽原联合检测在心肺复苏成功后患者近期预后评估中应用价值的研究

发布时间：2019-03-06 22:02

【摘要】：目的 :探讨血清生长分化因子-15(GDF-15)与N末端B型利钠肽原(NT-pro BNP)联合检测在心肺复苏(CPR)成功后患者近期预后评估中的应用价值。方法:选取我院心脏骤停CPR成功的患者共102例,分别检测其CPR后即刻、12 h、24~48 h的血清GDF-15水平,并根据血清GDF-15水平升高时间分为3组,A组(31例):CPR后即刻、12 h和24~48 h血清GDF-15水平一直1200 ng/L;B组(35例):CPR后12 h和24~48 h血清GDF-15水平持续升高,且一直1200 ng/L;C组(36例):CPR后12 h和24~48 h血清GDF-15水平持续升高,但24~48 h较12 h时降低。同时检测3组患者各时间点血清NT-pro BNP水平及左心室射血分数(LVEF)。随访3组患者CPR后6个月的死亡情况。结果:血清GDF-15和NT-pro BNP具有交互作用(P0.05),即NT-pro BNP表达水平随着血清GDF-15水平变化而变化;血清GDF-15与LVEF呈负相关(r=-0.530,P0.001)。血清GDF-15水平高表达者(1800 ng/L)、血清NTpro BNP水平高表达者(400 pg/ml)死亡率均高于血清GDF-15、NT-pro BNP水平低表达者(P0.05);生存分析结果显示,B组患者6个月生存率低于A组及C组(P0.05);A组和C组比较,差异无统计学意义(P0.05)。结论:血清GDF-15与NT-pro BNP联合检测能较好地预测CPR患者的近期临床预后。
[Abstract]:Aim: to investigate the value of combined detection of serum growth differentiation factor-15 (GDF-15) and N-terminal B-type natriuretic peptide (NT-pro BNP) in evaluating the short-term prognosis of patients after successful cardiopulmonary resuscitation (CPR). Methods: a total of 102 CPR patients with cardiac arrest in our hospital were selected. Serum GDF-15 levels were measured immediately, 12 h, and 24 h after CPR, and were divided into 3 groups according to the time when the serum GDF-15 level increased. Group A (31 cases immediately after): CPR) was divided into 3 groups: group A (n = 31), and group A (n = 31). 12 h and 24 h 48 h serum GDF-15 levels remain at 1200 ng/L; The level of serum GDF-15 in group B (n = 35) was higher than that in group B (n = 35) at 12 h and 24 h after): CPR, and the serum GDF-15 level in group B (n = 36) was higher than that in group B (n = 36) at 12 h and 24 h after): CPR (n = 36), but decreased at 24 h (P < 0. 05). At the same time, the levels of serum NT-pro BNP and left ventricular ejection fraction (LVEF).) were measured at different time points in three groups. All patients were followed up for 6 months after CPR. Results: there was interaction between serum GDF-15 and NT-pro BNP (P0.05), that is, the expression level of NT-pro BNP changed with the change of serum GDF-15 level, and there was a negative correlation between serum GDF-15 and LVEF (r = 0.530, P0.001). The mortality of patients with high expression of serum GDF-15 (1800 ng/L) and high expression of serum NTpro BNP (400 pg/ml) was higher than that of those with low expression of serum GDF-15,NT-pro BNP (P0.05). The results of survival analysis showed that the 6-month survival rate of group B was lower than that of group A and C (P0.05); A group and C group, there was no significant difference (P0.05). Conclusion: the combined detection of serum GDF-15 and NT-pro BNP can predict the short-term clinical prognosis of CPR patients.
【作者单位】：承德市中心医院急诊科;
【基金】：承德市科学技术研究与发展计划项目(20142009)
【分类号】：R459.7

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