碳青霉烯类抗菌药物对大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌、鲍曼不动杆菌的防突变浓度研究
发布时间：2019-03-25 14:43
【摘要】：目的:探索碳青霉烯类抗菌药物对临床分离的100株大肠埃希菌、肺炎克雷伯菌β-内酰胺酶表型和铜绿假单胞菌、鲍曼不动杆菌的防突变浓度(MPC)。方法:采用琼脂稀释法测定碳青霉烯类(亚胺培南、美洛培南、厄他培南和多利培南)对临床分离的革兰阴性耐药菌株的最低抑菌浓度(MIC)及MPC并计算MPC/MIC比值。采用WHONET5.6及SPASS13.0进行分析。结果:肠杆菌科细菌和鲍曼不动杆菌的MPC/MIC比值为2~4,铜绿假单胞菌为4-≥16。β-内酰胺酶阳性的肺炎克雷伯菌、大肠埃希菌MPC/MIC比值高于β-内酰胺酶阴性菌株(4至16μg·mL-1)。结论:基于MPC的碳青霉烯类抗菌药物可以通过MPC/MIC比值调整给药剂量,降低耐药菌株的总体数量和感染负荷,抑制耐药菌突变体的选择性富集扩增。
[Abstract]:Objective: to investigate the effects of carbapenems on 尾-lactamase phenotypes of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii in 100 clinical isolates of Escherichia coli and Acinetobacter baumannii (MPC). Methods: the minimal inhibitory concentrations (MIC) and MPC of carbapenems (imipenem, meropenem, etapenem and dolipenem) against clinically isolated Gram-negative drug-resistant strains were determined by Agar dilution method. The MPC/MIC ratio was calculated. WHONET5.6 and SPASS13.0 were used for analysis. Results: the MPC/MIC ratio of Enterobacteriaceae to Acinetobacter baumannii was 2? 4, Pseudomonas aeruginosa was 4-鈮，
本文编号：2447068
[Abstract]:Objective: to investigate the effects of carbapenems on 尾-lactamase phenotypes of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii in 100 clinical isolates of Escherichia coli and Acinetobacter baumannii (MPC). Methods: the minimal inhibitory concentrations (MIC) and MPC of carbapenems (imipenem, meropenem, etapenem and dolipenem) against clinically isolated Gram-negative drug-resistant strains were determined by Agar dilution method. The MPC/MIC ratio was calculated. WHONET5.6 and SPASS13.0 were used for analysis. Results: the MPC/MIC ratio of Enterobacteriaceae to Acinetobacter baumannii was 2? 4, Pseudomonas aeruginosa was 4-鈮，
本文编号：2447068
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