3种方法测定替加环素对鲍曼不动杆菌的体外药敏结果比较

发布时间：2019-05-18 08:30

【摘要】：比较替加环素对鲍曼不动杆菌的体外药敏试验不同方法之间的差异。分别采用微量肉汤稀释法、琼脂稀释法和K-B法测定119株临床分离鲍曼不动杆菌对替加环素的敏感性,比较不同检测方法结果的差异。微量肉汤稀释法MIC_(50)0.5μg/m L、MIC901μg/m L,FDA/EUCAST的耐药率0.0%(0/119)/0.0%(0/119),中介率0.0%(0/119)/5.0%(6/119),敏感率100%(119/119)/95.0%(113/119);琼脂稀释法MIC_(50)1μg/m L、MIC904μg/m L,FDA/EUCAST耐药率11.7%(14/119)/45.4%(54/119),中介率33.6%(40/119)/21.0%(25/119),敏感率54.7%(65/119)/33.6%(40/119);K-B法Jone/EUCAST的敏感率47.1%(56/119)/31.9%(38/119)、中介率48.74%(58/119)/31.9%(38/119),耐药率4.2%(5/119)/36.2%(43/119)。替加环素对鲍曼不动杆菌体的外药敏实验中,微量肉汤稀释法、琼脂稀释法和K-B法之间存在差异。以微量肉汤稀释法为参考方法,MH琼脂稀释法总误差41.2%~60.5%,K-B法总误差47.9%~63.9%。
[Abstract]:To compare the difference of drug sensitivity test of tegacycline to Acinetobacter baumannii in vitro. The sensitivity of 119 clinical isolates of Acinetobacter baumannii to tegacycline was determined by micro broth dilution method, Agar dilution method and K 鈮，

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