新型布尼亚病毒感染病原学检测与预后研究
发布时间：2019-05-21 18:17
【摘要】：目的通过回顾性分析新型布尼亚病毒感染患者继发细菌或真菌感染,探索高载量新型布尼亚病毒感染与预后相关性,为临床诊治危重症患者提供参考依据。方法对医院2013年9月-2015年9月收治70例发热伴血小板减少综合征病例资料进行回顾性分析,比较病程中培养结果和布尼亚核酸检测结果与患者预后相关性,数据采用SPSS 20.0软件进行统计分析。结果患者以中老年农民为主,多在5~7月份发病,17.39%患者有明确蜱叮咬史;共分离10株病原菌,以曲霉菌为主,共3株占30.00%;23例布尼亚病毒核酸阳性,其中重症患者死亡5例,痊愈患者18例。结论出现感染性休克的患者预后差,病死率高;在诊疗过程中,宜采取有效抗感染治疗方案和对症支持治疗,尤其对于重症患者需加强实验室指标的监测和病情监护。
[Abstract]:Objective to analyze the secondary bacterial or fungal infection in patients with new Bunia virus infection, and to explore the relationship between high load Bunia virus infection and prognosis, so as to provide reference for clinical diagnosis and treatment of critically ill patients. Methods the data of 70 cases of fever complicated with thrombopenia syndrome treated in hospital from September 2013 to September 2015 were analyzed retrospectively. the correlation between the results of culture and Bunia nucleic acid test and the prognosis of the patients was compared. The data were statistically analyzed by SPSS 20.0 software. Results most of the patients were middle-aged and elderly farmers, most of them occurred from May to July, 17.39% of the patients had a definite history of ticks bite, 10 strains of pathogenic bacteria were isolated, mainly Aspergillus, 3 strains accounted for 30.00%. There were 23 cases of Bunia virus nucleic acid positive, of which 5 cases died and 18 cases were cured. Conclusion the prognosis of patients with septic shock is poor and the fatality rate is high. In the process of diagnosis and treatment, effective anti-infection treatment and symptomatic support treatment should be taken, especially for severe patients, the monitoring of laboratory indexes and condition monitoring should be strengthened.
【作者单位】： 安徽医科大学第二附属医院肝病科;安徽大学经济学院经济统计系;
【基金】：安徽高校省级自然科学基金资助项目(KJ2014A107)
【分类号】：R446.5
[Abstract]:Objective to analyze the secondary bacterial or fungal infection in patients with new Bunia virus infection, and to explore the relationship between high load Bunia virus infection and prognosis, so as to provide reference for clinical diagnosis and treatment of critically ill patients. Methods the data of 70 cases of fever complicated with thrombopenia syndrome treated in hospital from September 2013 to September 2015 were analyzed retrospectively. the correlation between the results of culture and Bunia nucleic acid test and the prognosis of the patients was compared. The data were statistically analyzed by SPSS 20.0 software. Results most of the patients were middle-aged and elderly farmers, most of them occurred from May to July, 17.39% of the patients had a definite history of ticks bite, 10 strains of pathogenic bacteria were isolated, mainly Aspergillus, 3 strains accounted for 30.00%. There were 23 cases of Bunia virus nucleic acid positive, of which 5 cases died and 18 cases were cured. Conclusion the prognosis of patients with septic shock is poor and the fatality rate is high. In the process of diagnosis and treatment, effective anti-infection treatment and symptomatic support treatment should be taken, especially for severe patients, the monitoring of laboratory indexes and condition monitoring should be strengthened.
【作者单位】： 安徽医科大学第二附属医院肝病科;安徽大学经济学院经济统计系;
【基金】：安徽高校省级自然科学基金资助项目(KJ2014A107)
【分类号】：R446.5
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