2014年广西壮族自治区细菌耐药性监测情况分析

发布时间：2019-06-07 17:24

【摘要】：目的了解广西地区临床分离细菌的分布及其对常用抗菌药物的耐药性。方法对2014年广西地区37家主要医院临床分离的细菌采用自动化仪器法或纸片扩散法按统一方案进行细菌药敏实验,按CLSI2014年版判读药敏结果。结果 2014年广西地区收集各临床分离细菌73868株,其中革兰阴性菌53814株,占72.9%,革兰阳性菌20054株,占27.1%。耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)的检出率分别为31.8%和77.9%,未发现万古霉素、利奈唑胺耐药的葡萄球菌。万古霉素耐药粪肠球菌和屎肠球菌分别占1.1%和1.4%,耐青霉素肺炎链球菌为2.0%。肠杆菌科细菌对碳青酶烯类抗生素耐药率大多在10.0%以下。铜绿假单胞菌对亚胺培南的耐药率为11.3%,鲍曼不动杆菌对亚胺培南和头孢噻肟、左氧氟沙星等耐药率超过40.0%。结论广西地区细菌耐药情况较为严重;应加强抗生素的合理应用和耐药性监测,采取有效的控制措施。
[Abstract]:Objective to investigate the distribution of clinical isolated bacteria and their resistance to commonly used antibiotics in Guangxi. Methods the bacteria isolated from 37 major hospitals in Guangxi in 2014 were tested by automatic instrument method or disk diffusion method according to the unified scheme, and the drug sensitivity results were read according to the 2014 version of CLSI. Results in 2014, 73868 strains of clinical bacteria were collected in Guangxi, including 53814 strains of Gram-negative bacteria (72.9%) and 20054 strains of Gram-positive bacteria (27.1%). The detection rates of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase negative Staphylococcus (MRCNS) were 31.8% and 77.9%, respectively. No vancomycin and linazolamide resistant staphylococci were found. Vancomycin resistant Enterococcus faecium and Enterococcus faecium accounted for 1.1% and 1.4% respectively, and penicillin resistant Streptococcus pneumoniae was 2.0%. The resistance rate of Enterobacteriaceae to carbinase antibiotics was less than 10.0%. The resistance rate of Pseudomonas aeruginosa to imipenem was 11.3%, and that of Acinetobacter baumannii to imipenem, cefotaxime and levofloxacin was more than 40.0%. Conclusion the drug resistance of bacteria in Guangxi is serious, the rational use of antibiotics and drug resistance monitoring should be strengthened, and effective control measures should be taken.
【作者单位】：广西壮族自治区人民医院广西壮族自治区临床检验中心;广西壮族自治区人民医院检验科;
【基金】：广西卫计委科研课题(No.Z2014222)
【分类号】：R446.5

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