纳米水分散体系的瞬时纳米制备研究及技术应用

发布时间：2018-01-04 20:26

本文关键词：纳米水分散体系的瞬时纳米制备研究及技术应用　出处：《扬州大学》2017年硕士论文　论文类型：学位论文

【摘要】：纳米悬浮液和纳米乳液均属于典型的胶体材料。由于拥有纳米级别的尺寸,展现出独特的物理和化学性质,如粘度低、扩散渗透性强、比表面积大、生物利用率高等优点,在医学示踪、制药、食品、化妆品、农药、石化、机械加工等领域具有广泛的应用。本论文尝试提出胶体材料制备新概念,发展胶体材料制备新方法,拓展该技术在各领域内的应用,并为建立完备技术奠定理论基础和框架。具体工作为:1)以近年出现的瞬时纳米析出法(FNP)为基础,制备了具有聚集诱导发光(AIE)效应的纳米颗粒;2)从药物示踪的实际应用出发,首次研究了颗粒粒径、药物分子共轭基团、高分子玻璃化转变温度及油状添加物对荧光发光强度的影响;3)首次提出瞬时纳米乳化(FNE)的方法,并提出瞬时纳米制备(FNF)技术的新概念,探究了乳液形成的机理,优化了材料制备的配方,技术上实现了 FNE的简易操作;5)将FNE技术应用到基础油乳液的制备,探究控制所形成乳液尺寸的因素,对应用中油类的预测选择及乳液制备方案的事先确定具有重要的科学指导意义。第二章使用疏水性强的四苯基乙烯(TPE,ACDLogP = 8.41)作为目标分子,两亲性嵌段共聚物mPEG(5k)-b-PLGA(10k)作为稳定剂,通过瞬时纳米析出法得到了粒径在100 nm左右的具有优秀AIE效应的荧光纳米颗粒,首次讨论了荧光强度随粒径增大而减小的规律。并以药物示踪为应用模板研究了乳液、药物和高分子辅料对共混后荧光纳米颗粒的影响,研究了共轭结构、高玻璃化转变温度和油状化合物对聚集诱导发光强度的猝灭效应。该工作在制备AIE纳米制剂时对小分子药物、高分子辅料、及油类的选取具有重要的指导意义。第三章提出并发展了 FNE技术。通过使用疏水性高的红桔精油(ACDLogP = 4.37)作为模型油,分别使用吐温80和mPEG-b-PLGA作为表面活性剂,成功制备出最低液滴直径16 nm的纳米乳液。并对配方进行优化,证实了高分子乳化剂比吐温80用量更少,粒径更小。通过改变混合雷诺数获得雷诺数与粒径及时间稳定性的关系,确定了 FNE所需充分混合的最低雷诺数为2200。将含盐与无盐体系乳液zeta电位和粒径进行对比证实了稳定机理为乳化剂位阻作用。另外,通过比较粒径稳定性证实了 FNE法比传统滴加搅拌法更具有小粒径、窄分布和高稳定性的优势。该技术为满足化工、农业、医疗等广泛领域对纳米乳液大量需求开辟了新道路。第四章将FNE的应用领域拓展到基础油。使用了吐温80、mPEG-b-PLGA、APG(8-10和8-14)为表面活性剂,对矿物油和煤油乳液的配方进行优化,得到了粒径约100 nm的矿物油纳米乳液和粒径约35 nm的煤油纳米乳液。并以含硅表面活性剂和二氧化硅小球(10 nm)为表面活性剂,探索制备了硅油乳液。通过对油水界面张力的测量,计算了毛细管数,获得油相和表面活性剂选择对乳液初始液滴大小的影响。并评价了煤油水乳液对金属表面油污的清洗性能和矿物油水乳液对金属表面的润滑性能。该工作拓展了 FNE的使用范围,对FNE使用中油相的预选和配方的设计提供了重要的理论指导。
[Abstract]:Nano suspension and nano emulsion colloid materials belong to typical. With nano scale size, exhibit unique physical and chemical properties, such as low viscosity, diffusion and permeability, large surface area, high bioavailability and advantages in medical, pharmaceutical, food, tracer, cosmetics, pesticides, petrochemicals. With the extensive application of mechanical processing and other fields. This paper tries to put forward the new concept for preparing colloidal materials, development of colloid materials preparation methods, application of the technology in various fields, and laid the theoretical foundation and framework for the establishment of complete technology. The main work includes: 1) the instantaneous nano precipitation method appeared in recent years (FNP) as the foundation, was prepared with aggregation induced emission (AIE) nanoparticles effect; 2) starting from the actual application of drug tracing was studied for the first time, particle size, molecular conjugated polymer, glass transition temperature and oil Tim With the influence on the luminescence intensity of fluorescence; 3) first proposed instantaneous nano emulsion (FNE) method, and put forward the instantaneous nano preparation (FNF) new concept and technology, to explore the mechanism of emulsion formation, optimize the material preparation formula, the technology to realize the simple operation of FNE; 5) FNE technology is applied to the base oil emulsion preparation, control of formation factors of emulsion size, scheme selection and prediction of oil emulsion preparation using the previously determined has important scientific significance. The second chapter uses four phenyl ethylene hydrophobic (TPE, ACDLogP = 8.41) as the target molecule, two Pro block copolymer mPEG (5K) -b-PLGA (10K) as the stabilizer, the instantaneous nano precipitation method has been size of about 100 nm and has a good effect of AIE particle fluorescent nanoparticles was discussed for the first time, the fluorescence intensity increases with the particle size decreases by medicine and law. Study on the application of tracer emulsion as template. The effect of drugs and excipients on polymer blend nanoparticles, study the conjugate structure, high glass transition temperature and oil quenching effect of compound aggregation induced emission intensity. The work in the preparation of AIE nano preparation of small molecule drugs, polymer materials, has an important guide selection and oil. In the third chapter, proposed and developed by FNE technology. The high hydrophobicity of tangerine essential oils (ACDLogP = 4.37) were used as model oil, Twain 80 and mPEG-b-PLGA as a surfactant to produce nanometer emulsion minimum droplet diameter of 16 nm. And the optimized formulation. Confirmed that the polymer emulsifier amount less than the Twain 80, a smaller size. By changing the mixed relationship between Reynolds number and the Reynolds number of particle size and time stability, determine the FNE required to fully mix the most Low Reynolds number of 2200. will be salt and salt free emulsion system of zeta potential and particle size were compared and confirmed the stable mechanism of emulsifier steric effect. In addition, by comparing the particle size stability confirmed the FNE dropping more than traditional mixing method has small particle size, narrow size distribution and high stability advantages. This technology to meet the chemical industry agriculture, medical and other fields, has opened up a new way for nano emulsion. The fourth chapter will demand the application of FNE to expand the base oil. The use of the Twain 80, mPEG-b-PLGA, APG (8-10 and 8-14) as the surfactant, the mineral oil and kerosene emulsion formulation was optimized, by kerosene nano emulsion mineral oil emulsion and nano particle size of about 100 nm diameter of about 35 nm. And the surfactant containing silicon and silica particles (10 nm) as the surfactant, explore the silicone oil emulsion was prepared. Through the measurement of interfacial tension, calculation The capillary number, obtain oil and surfactant of emulsion initial droplet size. And evaluate the cleaning performance and mineral oil-water emulsion on the metal surface greasy dirt water kerosene emulsion on lubrication performance of the metal surface. This work extends the use of FNE, provides an important theoretical guidance for the design of pre FNE and with oil formula.

【学位授予单位】：扬州大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：TB383.1

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