生物分子“盖帽”的介孔硅药物控释系统

发布时间：2018-01-05 11:19

本文关键词：生物分子“盖帽”的介孔硅药物控释系统　出处：《功能材料》2017年04期 　论文类型：期刊论文

【摘要】：介孔硅纳米颗粒在药物控释系统中具有重要的科研价值和广阔的应用前景,这方面的研究已成为当今生物医药领域共同研究热点之一。而生物分子由于其生物相容性好、可降解、无毒副作用、靶向性强等优点被广泛应用于修饰介孔硅纳米颗粒。综述了用不同种类生物分子作为"帽子"修饰介孔硅的研究进展,着重介绍生物分子与介孔硅表面的连接作用方式及脱离机制。最后还对当前研究的热点及研究中存在的问题进行了评述与展望,希望为药物控释体系未来的研究提供借鉴与思路。
[Abstract]:Mesoporous silica nanoparticles in drug control has important scientific research value and wide application prospect of release system, this research has become the field of biology and medicine joint research hotspot. And molecular biology because of its good biocompatibility, biodegradable, non-toxic side effects, strong targeting is widely used in the modification of mesoporous silica nanoparticles are reviewed. With different kinds of biological molecules as "modified mesoporous silicon research, emphatically introduces the connection mode of action of biological molecules and mesoporous silicon surface and detachment mechanism. Finally the existing research hotspots and problems in current research were reviewed and prospects, hope to control release of future system to provide reference and train of thought for the drug.

【作者单位】：福州大学化学学院;
【基金】：国家自然科学基金资助项目(21271044)
【分类号】：R943;TB383.1
【正文快照】： 0引言近十几年来,随着纳米技术的迅速发展,基于纳米制备技术发展的功能纳米材料在药物控释系统应用也越来越广泛。有序介孔硅纳米颗粒(mesoporous silicananopaticles,MSN)具有吸附量大、比表面积大、孔道均匀排列、表面可控官能化、物理稳定性、生物相容性和孔径可调等诸多优

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