基于DMBA反应活性形状记忆聚氨酯的制备与表征

发布时间：2018-01-18 05:19

本文关键词：基于DMBA反应活性形状记忆聚氨酯的制备与表征　出处：《功能材料》2017年10期 　论文类型：期刊论文

更多相关文章： 形状记忆性 功能化 羧基 聚氨酯 DMBA

【摘要】：通过溶液聚合法,将既作为扩链剂又作为改性剂且富含COOH功能性基团的二羟甲基丁酸(DMBA)引入到聚氨酯硬段中,合成了一种反应性的形状记忆聚氨酯(PUU-COOH)。随后,以1-乙基-(3-二甲基氨基丙基)碳二亚胺盐酸盐(EDC)为缩合剂,使四肽(RGDS)中NH2与PUU-COOH中COOH反应合成PUU-RGDS生物活性材料,对PUU-COOH的中COOH可反应性进行了验证。利用傅里叶变换红外光谱仪(FT-IR)、核磁共振仪(1 H NMR)、凝胶渗透色谱(GPC)、差示扫描量热法(DSC)、拉伸测试及罗丹明染色法和酸碱滴定法表征了PUU-COOH的结构和基本性能。结果表明,DMBA成功引入到聚氨酯中,且合成的PUU-COOH既含有活性功能团又具有形状记忆性,可进一步接入生物活性分子,从而为制备促细胞生长和削弱应力遮挡的生物活性形状记忆性智能材料提供一种基础材料。
[Abstract]:By solution polymerization, dihydroxymethyl butyrate (DMBA), both as chain extender and modifier and rich in functional groups of COOH, was introduced into rigid segment of polyurethane. A kind of reactive shape memory polyurethane (PUU-COOHH) was synthesized, and then EDC1 ethyl-3-dimethyl aminopropyl) carbodiimide was used as the shrinkage agent. The PUU-RGDS bioactive material was synthesized by the reaction of NH2 in tetrapeptide RGDS with COOH in PUU-COOH. The reactivity of COOH in PUU-COOH was verified by Fourier transform infrared spectroscopy (FTIR) and 1H NMRs. The structure and basic properties of PUU-COOH were characterized by gel permeation chromatography (GPC), differential scanning calorimetry (DSC), tensile test, Rhodamine staining and acid-base titration. DMBA was successfully introduced into polyurethane, and the synthesized PUU-COOH not only contains active functional groups but also has shape memory, which can be further connected to bioactive molecules. Therefore, it provides a basic material for the preparation of bioactive shape memory smart materials that promote cell growth and reduce stress occlusion.
【作者单位】：重庆大学生物工程学院生物材料与仿生工程研究中心;重庆大学生物流变科学与技术教育部重点实验室;
【基金】：国家自然科学基金资助项目(NSFC 31370946) 重庆市应用研究资助项目(cstc2014yykfC50002)
【分类号】：TB381;TQ317
【正文快照】： 0引言形状记忆聚氨酯是一类由软段和硬段共价结合构成的具有形状记忆性能的一种新型的智能材料[1]。其中,热致形状记忆材料制备的医疗替代物可以通过微创手术或者腹腔镜被轻松植入体内后,在体温下回复到适宜大小的永久形状,减少创口面积且不需要其它进行刺激的辅助工具[1-2]。

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