三聚磷酸钠改性聚氨酯纳米粒子的合成及表征

发布时间：2018-02-28 14:37

本文关键词： 聚氨酯纳米粒子三聚磷酸钠细胞毒性实验　出处：《南京工业大学学报(自然科学版)》2016年06期 　论文类型：期刊论文

【摘要】：以二苯基甲烷-4,4′-二异氰酸酯(MDI)、聚四氢呋喃醚二醇(PTMG)为主要原料,二羟基甲基丙酸(DMPA)作为功能单体,异丙醇作为封端剂,并以三乙胺中和,制得聚氨酯离聚物(PUI)。再用十二烷基硫酸钠溶液以及三聚磷酸钠(STP)溶液处理,制得表面修饰的聚氨酯粒子(PUI-STP)。用透射电子显微镜(TEM)、扫描电子显微镜(SEM)、马尔文粒度分布仪、核磁共振仪(NMR)及X线光电子能谱仪(XPS)对样品进行表征。结果表明:粒子为圆球形,大小较为均一,平均粒径为179.2 nm,达到了纳米尺度,且PUI-STP中增加了大量P元素,说明三聚磷酸根已经被成功引入到聚氨酯纳米粒子表面。红细胞体外试验结果表明该纳米粒子具有良好的血液相容性,细胞毒性实验结果表明该纳米粒子具有良好的细胞相容性。
[Abstract]:In this paper, diphenyl methane-4- (4-diisocyanate) -diisocyanate (MDI), polytetrahydrofuranediol (PTMG), dihydroxymethyl propionate (DMPA) as functional monomer, isopropanol as capping agent, and triethylamine were used as the main raw materials, and then neutralized with triethylamine. Polyurethane ionomer was prepared, then treated with sodium 12 alkyl sulfate solution and sodium tripolyphosphate solution, the surface modified polyurethane particle PUI-STP was prepared by means of transmission electron microscope (TEM), scanning electron microscope (SEM), and Ma Erwen particle size distribution instrument. The samples were characterized by NMR and X-ray photoelectron spectroscopy (XPS). The results showed that the particles were spherical, uniform in size, and the average particle size was 179.2 nm, which reached the nanoscale size, and a large number of P elements were added to the PUI-STP. The results show that the tripolyphosphate has been successfully introduced to the surface of polyurethane nanoparticles. The results of erythrocyte test in vitro show that the nanoparticles have good blood compatibility. The results of cytotoxicity test showed that the nanoparticles had good cytocompatibility.
【作者单位】：扬州市职业大学生物与化工工程学院;扬州大学化学化工学院;
【基金】：江苏省高等职业院校国内高级访问学者计划(FX013)
【分类号】：TB383.1

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