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基于亲疏水转换的智能无封堵纳米阀门

发布时间:2018-03-18 20:11

  本文选题:纳米材料 切入点:纳米阀门 出处:《北京科技大学》2017年博士论文 论文类型:学位论文


【摘要】:随着纳米技术的蓬勃发展,实现宏观尺度机械的微小型化拥有十分广阔的前景。已经有越来越多的化学家与工程师在分子水平和超分子水平上开发出了纳米尺度的机器。纳米阀门,是一种可以控制分子进出纳米孔的纳米尺度的机器。纳米阀门在分离、化学和生物传感器、化学存储、精准医疗等领域拥有广阔的应用前景。本论文设计了一种基于亲疏水转换的无封堵纳米阀门,并且通过引入光子晶体赋予其传感能力。主要内容如下:1、我们以二氧化硅为载体,设计了一种基于亲疏水转换的电刺激响应无封堵控制释放体系,实现了无封堵纳米阀门的初步构建。利用共缩聚法,将具有亲疏水转换性质的功能分子修饰在介孔孔道内侧,修饰后的孔道可以通过改变自身对水的浸润性来控制药物的释放行为。这种药物控释体系不同于对依赖于实体封堵的控释体系,制备和负载药物过程简单而高效,并且无由封堵物带来的各种毒副作用,具有很强的实际应用潜力。2、我们基于介孔反Opal光子晶体,通过共缩聚法修饰苯胺基团到介孔反Opal光子晶体结构中,制备了 pH响应的无封堵纳米阀门,实现了无封堵纳米阀门的自传感。苯胺基团具有pH响应的亲疏水转换特性,在pH为中性条件下,处于疏水状态,阀门关闭,而此时光子晶体薄膜显示为绿色。而在pH为酸性环境下,苯胺变为亲水状态,阀门开启,而此时光子晶体薄膜随着溶液的侵入程度显示为黄色到红色。该阀门不仅实现了无封堵控制,而且实现了阀门状态的无指示剂传感,为光子晶体传感器和纳米阀门传感提供了新的思路和前景。3、我们基于介孔反Opal光子晶体,通过后修饰法将二茂铁功能基团修饰到介孔反Opal光子晶体结构中,制备了电响应的无封堵纳米阀门,并且将其用于控制释放的实时传感。二茂铁具有电场响应的亲疏水转换特性,在未加电刺激时处于疏水状态,阀门关闭,药物封装在介孔反Opal光子晶体内。当施加电刺激后,二茂铁发生电氧化转变为亲水态,阀门开启,溶液侵入导致药物释放,同时光子晶体颜色发生改变。该反Opal光子晶体控制释放系统不仅实现了无封堵控制释放,更实现了控制释放状态的实时监测,为控制释放和及其传感提供了新的思路和前景。
[Abstract]:With the rapid development of nanotechnology, Microminiaturization of macro-scale machinery has a very broad prospect. More and more chemists and engineers have developed nanoscale machines, nanovalves, at both molecular and supramolecular levels. Is a nano-scale machine that controls the flow of molecules into and out of nanopores. Nanovalves are in separation, chemical and biological sensors, chemical storage, In this paper, a kind of unplugged nano-valve based on hydrophilic conversion is designed, and the sensing ability is given by introducing photonic crystal. The main contents are as follows: 1, we use silica as carrier. Based on hydrophilic conversion, an electrically stimulated unplugged controlled release system was designed to realize the preliminary construction of unplugged nano-valves. The functional molecules with hydrophilic conversion properties were modified on the inner side of mesoporous channels by co-condensation. The modified pore can control the release behavior of the drug by changing its own wettability to water. This drug controlled release system is different from the controlled release system which depends on the solid plugging. The preparation and loading of the drug is simple and efficient. Moreover, there are no toxic and side effects caused by plugging materials, so it has strong practical application potential. Based on mesoporous inverse Opal photonic crystal, we modify aniline group into mesoporous reverse Opal photonic crystal structure by co-condensation method. An unplugged nano-valve with pH response was prepared to realize the autobiographical sensation of the valve. The aniline group has the hydrophilic conversion characteristic of pH response, which is in the hydrophobic state under the condition of neutral pH, and the valve is closed. At this point, the photonic crystal film is shown to be green. When pH is acidic, aniline becomes hydrophilic and the valve opens. At this time, the photonic crystal film is shown to be yellow to red with the invasion degree of the solution. The valve not only has no plugging control, but also realizes the non-indicator sensing of the valve state. It provides a new idea and prospect for photonic crystal sensor and nano-valve sensor. Based on mesoporous inverse Opal photonic crystal, we modify ferrocene functional group into mesoporous inverse Opal photonic crystal structure by post modification method. An electrically responsive unplugged nano-valve was prepared and used for real-time sensing of controlled release. Ferrocene has hydrophilic conversion characteristics of electric field response and is in a hydrophobic state without electrical stimulation and the valve is closed. The drug is encapsulated in a mesoporous inverse Opal photonic crystal. After electrical stimulation, ferrocene is electrooxidized to a hydrophilic state, the valve opens, and the solution invades causing the drug to be released. At the same time, the color of photonic crystal is changed. The control release system of anti-#en0# photonic crystal not only realizes the controlled release without plugging, but also realizes the real-time monitoring of the state of controlled release, which provides a new idea and prospect for the control release and its sensing.
【学位授予单位】:北京科技大学
【学位级别】:博士
【学位授予年份】:2017
【分类号】:TB383.1;O734

【参考文献】

相关期刊论文 前1条

1 Yu-Jie Chang;Xi-Zhen Liu;Qing Zhao;Xiao-Hai Yang;Ke-Min Wang;Qing Wang;Min Lin;Meng Yang;;P(VPBA-DMAEA) as a pH-sensitive nanovalve for mesoporous silica nanoparticles based controlled release[J];Chinese Chemical Letters;2015年10期



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