甲基乙烯基硅橡胶表面亲水性改性及其抗细菌粘附性能的研究

发布时间：2018-03-19 21:21

本文选题：甲基乙烯基硅橡胶　切入点：真空紫外　出处：《华南理工大学》2015年硕士论文　论文类型：学位论文

【摘要】：本论文采用高能量的真空紫外灯辐照甲基乙烯基硅橡胶表面,在其表面产生反应性位点,通过化学接枝或紫外光接枝反应分别将壳聚糖或其衍生物、磺铵两性离子以共价键形式接枝于硅橡胶表面,从而改善硅橡胶表面的亲水性,并研究改性后的硅橡胶表面的抗细菌粘附性能。研究发现:(1)采用172nm Xe2*真空紫外灯辐照硅橡胶200s后,水在硅橡胶表面的接触角由102.5°变为硅橡胶表面完全浸润,亲水性得到很大改善,在自然环境中放置120h后硅橡胶表面的水接触角变为94.3°,亲水性表面转变为疏水性;(2)采用苯甲醛与壳聚糖反应保护壳聚糖C2上的-NH2并脱去,使C6上的-OH发生亲核取代反应接枝季铵盐侧链,可以合成水溶性并保留C2上活泼基团-NH2的季铵化壳聚糖;利用壳聚糖或其衍生物上的氨基与活化后的硅橡胶表面的硅醇反应,通过化学键成功地将壳聚糖或其衍生物接枝在硅橡胶表面,接枝后的硅橡胶表面与水的接触角分别为67.2°和54.8°,在自然环境放置168h后接触角仍只有81.8°和69.7°,具有较长久的亲水性保持性;(3)通过1,3-丙磺酸内酯(PS)与N-(3-二甲氨基丙基)甲基丙烯酰胺(DMAPMA)的亲核取代反应成功合成含有双键的磺基甜菜碱型两性离子;采用紫外光接枝反应在硅橡胶表面成功接枝磺铵两性离子,当两性离子单体浓度为8wt%、光引发剂浓度为4wt%及紫外光固化时间为20min时,硅橡胶表面接枝两性离子效果最好,其表面接触角为38.5°,亲水性得到明显改善,并且在自然环境中放置168h后只有66.9°,具有较好的亲水性保持性;(4)将表面分别接枝壳聚糖衍生物、磺铵两性离子的硅橡胶样片分别与大肠杆菌和金黄色葡萄球菌接触培养24h,改性后的硅橡胶样片表面细菌粘附数量明显减少,表现出良好的抗细菌粘附性能,并且改性后硅橡胶表面抗金黄色葡萄球菌的粘附性能要优于大肠杆菌。
[Abstract]:In this paper, high energy vacuum ultraviolet lamp was used to irradiate the surface of methyl vinyl silicone rubber, and reactive sites were generated on the surface of methyl vinyl silicone rubber. Chitosan or its derivatives were chemically grafted or UV grafted, respectively. The amphoteric ion of ammonium sulfonate grafted on the surface of silicone rubber in the form of covalent bond, thus improving the hydrophilicity of the surface of silicone rubber. The bacteriological adhesion of modified silicone rubber surface was also studied. It was found that the contact angle of water on the surface of silicone rubber changed from 102.5 掳to complete infiltration of water on the surface of silicone rubber after irradiation with 172nm Xe2 * vacuum ultraviolet lamp for 200s. The hydrophilicity was greatly improved, the contact angle of water on the surface of silicone rubber was 94.3 掳after being placed in natural environment for 120 h, and the hydrophilic surface changed to hydrophobicity.) benzaldehyde reacted with chitosan to protect -NH _ 2 from removing -NH _ 2 on chitosan C2, and the hydrophilic contact angle became 94.3 掳, and the hydrophilic surface changed to hydrophobicity. The nucleophilic substitution reaction of -OH on C _ 6 was carried out to graft quaternary ammonium salt side chain, which could be used to synthesize water-soluble quaternary ammonium chitosan with active group -NH _ 2 on C _ 2. The amino groups on chitosan or its derivatives were used to react with silica alcohol on the surface of activated silicone rubber. The chitosan or its derivatives were successfully grafted onto the surface of silicone rubber by chemical bonds. The contact angles between the surface of grafted silicone rubber and water were 67.2 掳and 54.8 掳respectively. The contact angles were 81.8 掳and 69.7 掳after being placed in natural environment for 168 h. The nucleophilic substitution reaction of methacrylamide (DMAPMA) was used to synthesize the amphoteric ions containing double bonds of sulfobetaine. The amphoteric ion was successfully grafted on the surface of silicone rubber by UV grafting reaction. When the concentration of amphoteric monomer was 8 wt, the concentration of photoinitiator was 4wt% and the UV curing time was 20min, the effect of grafting amphoteric ion on the surface of silicone rubber was the best. The surface contact angle is 38.5 掳, the hydrophilicity is improved obviously, and only 66.9 掳after being placed in the natural environment for 168 h. The surface is grafted with chitosan derivatives respectively. The surface bacterial adhesion of the modified silicone rubber sample was significantly reduced and showed good anti-bacterial adhesion, when it was incubated with Escherichia coli and Staphylococcus aureus for 24 hours, respectively. The adhesion of modified silicone rubber to Staphylococcus aureus was superior to that of Escherichia coli.
【学位授予单位】：华南理工大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：TB306

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