磁性纳米粒子与荧光量子点复合颗粒制备与性能的研究

发布时间：2018-03-25 19:15

本文选题：荧光量子点　切入点：磁性纳米粒子　出处：《济南大学》2015年硕士论文

【摘要】：随着纳米科学技术的发展,科学工作者们已经成功制备出具有独特电、磁、光、热、生物、化学等性能的功能性纳米颗粒。这些功能性纳米颗粒对于生物、医学、电子、化学、材料等许多学科领域的发展具有重大意义,其中荧光量子点和磁性纳米材料因其优良的发光性能和磁学性能,在生物医学领域具有广泛应用。然而,随着科学技术的进一步发展,单一功能的材料已经不再满足人们对先进材料的需求,因此,如果将磁性和荧光相结合,集分离和标记功能于一体,通过一定的物理化学工艺制备出多功能磁性荧光纳米复合材料,使其可以作为荧光探针的同时,还具有良好的磁靶向性。基于此,本课题采用具有核磁共振造影剂作用的超顺磁性Fe3O4@SiO2为磁核提供磁性,以颜色可调、高发光效率的核壳结构的ZnSe@ZnS量子点提供荧光,通过微乳液法制备同时包埋磁性纳米粒子和荧光量子点的Si02微粒,实现磁性荧光双功能复合。这种复合纳米材料不仅拓展了其生物医学应用潜力,还能有效克服磁性四氧化三铁纳米粒子易被氧化、量子点对周围环境的敏感性及生物毒性等问题,使两种纳米粒子的应用范围进一步扩大。此外,为了完善Fe3O4@SiO2磁性纳米粒子的性能,采用化学还原法在其表面沉积一层银单质,旨在制备出具有核壳结构的MNPs/Ag磁性粒子。将贵金属纳米材料覆盖到磁性纳米材料表面,可以大幅改良原磁性纳米颗粒的稳定性,同时其本身的独特性质也能结合到复合材料中,这可以一定程度上拓展纳米材料的实用性。银纳米颗粒在可见光区和近红外光区的等离子体共振特性使得银纳米颗粒具有较高的光催化性能、杀菌作用、表面增强光谱、光学性能等,同时相对于金属金、钮、铀而言,金属银的价格较低,因此磁性纳米粒子与贵金属Ag的复合具有研究价值。本论文采用微乳液法制备磁性荧光双功能复合颗粒,以环己烷为连续相,TriotnX-100为表面活性剂,正己醇为助活性剂,体积比为4：1：1时,可得到适于反应的微乳液,通过紫外吸收光谱和荧光光谱分析得到最佳制备工艺参数为：当量子点与磁性粒子的摩尔比为5：1,TEOS和氨水的体积分数分别2.2%和3.2%,反应时间为24h时,所制备磁性荧光双功能复合颗粒的性能最好。制备的磁性荧光复合颗粒基本呈球形,粒径大小在70nm左右,稳定性良好,其抗光漂白性能相比于量子点有所增强,可放置很长一段时间,并且表现出良好的超顺磁性。本论文采用微乳液法制备的Fe3O4@SiO2磁性粒子颗粒基本成球形,分散性良好,粒径大小在40nm左右。Fe3O4@SiO2磁性粒子表现出良好的超顺磁性,但比纯Fe304磁性粒子的性能有所降低。本论文采用化学还原法在Fe3O4@SiO2磁性粒子表面沉积一层薄的Ag壳层,粒径大小改变不大,颗粒仍呈球形,分散性良好。MNPs/Ag磁性粒子表现出良好的超顺磁性,同时由于Ag壳层比较薄,其磁性能接近于Fe3O4@SiO2磁性粒子,并且Fe3O4@SiO2与AgNO3的摩尔比为1：0.4时制备的MNPs/Ag中Ag的重量百分比较大为6.39。
[Abstract]:With the development of nano science and technology, scientists have successfully prepared with unique electrical, magnetic, optical, thermal, biological, chemical and other properties of functional nanoparticles. These functional nanoparticles for biological, medical, electronic, chemical, material and other fields of many disciplines development is of great significance, including fluorescence quantum dots and magnetic nano materials because of its excellent luminescent properties and magnetic properties, is widely used in the biomedical field. However, with the further development of science and technology, single function material no longer meet the needs of people of advanced materials so that if the magnetic and fluorescent combination, set the isolation and labeling functions. Through physical and chemical process prepared by multifunctional magnetic fluorescent nanometer composite material, which can be used as a fluorescent probe at the same time, also has good magnetic targeting. Based on this, this lesson The problem with magnetic resonance imaging agent superparamagnetic magnetic Fe3O4@SiO2 as magnetic core, with adjustable color, ZnSe@ZnS quantum dots core-shell structure with high light-emitting efficiency and provide fluorescence by Si02 particles prepared by microemulsion method and embedding of magnetic nanoparticles and quantum dots, magnetic fluorescent bifunctional compound. Nano composite material not only expand its biomedical application potential, can effectively overcome the magnetic Fe3O4 nanoparticles are easily oxidized, quantum dots on environment sensitivity and biological toxicity and other issues, the two kinds of nano particles to further expand the scope of application. In addition, in order to improve the performance of Fe3O4@SiO2 magnetic nanoparticles by chemical reduction method, deposited on the surface of a layer of silver, in order to prepare MNPs/Ag magnetic particles with core-shell structure. The noble metal nano materials covered by magnetic nano materials The surface of the material can be greatly improved the stability of magnetic nanoparticles, and its unique properties can also be combined in composite materials, the practicability of this can to some extent development of nanomaterials. The silver nanoparticles in the plasma resonance characteristics of visible and near infrared region of the silver nanoparticles with high photocatalytic properties. Bactericidal effect, surface enhanced spectroscopy, optical properties, and compared with the metal button, gold, uranium, silver's price is low, so the composite has the research value of magnetic nanoparticles and noble metal Ag. Microemulsion preparation of magnetic fluorescent bifunctional composite particles used in this paper, by using cyclohexane as continuous phase, TriotnX-100 surface surfactant, hexanol as co surfactant, the volume ratio of 4:1:1, can be obtained for microemulsion reaction analysis, get the best preparation by UV Vis absorption spectra and fluorescence spectra The preparation process parameters: when the molar ratio of quantum dots and magnetic particles is 5:1, the volume fraction of TEOS and ammonia were 2.2% and 3.2%, the reaction time is 24h, the performance of preparation of magnetic fluorescent bifunctional composite particles. The best magnetic fluorescent composite particles prepared basically spherical particle size, good stability in 70nm so, photobleaching resistance compared to quantum dots has been enhanced, can be placed for a long period of time, and showed good superparamagnetism. This paper uses Fe3O4@SiO2 magnetic particles prepared by microemulsion was basically spherical and well dispersed, the particle size of.Fe3O4@SiO2 was about 40nm magnetic particles showed good the superparamagnetic properties of pure Fe304, but the ratio of magnetic particles decreased. This paper adopts the chemical reduction method Fe3O4@SiO2 magnetic particles deposited on the surface of a thin layer of Ag shell, the particle size did not change, still particles Spherical, well dispersed.MNPs/Ag nanoparticles exhibit good superparamagnetism, and because the Ag shell is very thin, close to the magnetic properties of Fe3O4@SiO2 magnetic particles, and the molar ratio of Fe3O4@SiO2 and AgNO3 1:0.4 MNPs/Ag prepared Ag weight percent larger for 6.39.

【学位授予单位】：济南大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：TB383.1

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