稀土基多模态纳米造影剂的最新研究进展

发布时间：2018-05-12 02:37

本文选题：稀土 + 纳米造影剂　；参考：《中国科学:化学》2017年02期

【摘要】：基于稀土元素特殊的电子结构、独特的光电磁性质及相对大的原子序数,近年来,多领域的科学家们将研究热点聚焦到稀土基纳米造影剂的理性合成及生物医学成像的相关研究上.长久以来,稀土元素的4f电子赋予其构建荧光探针的本能,稀土掺杂的上转换纳米材料已被广泛应用于荧光成像.因存在大量未配对的4f电子,钆离子修饰的纳米探针及基于钆的纳米材料常用于T_1加权磁共振成像.由于稀土元素相比碘元素具有更高的原子序数和更强的X射线衰减系数,稀土基纳米材料可用于X射线及X射线断层摄影术(CT)成像.本文将针对近年来稀土基多模态纳米造影剂的开发与应用进行介绍,综述其在生物医学领域的研究进展.
[Abstract]:Based on the special electronic structure of rare earth elements, unique optical and electromagnetic properties and relatively large atomic numbers, in recent years, many scientists have focused on the research of rational synthesis and biomedical imaging of rare earth based nanoscale contrast agents. For a long time, the 4f electrons of dilute earth elements have given them a fluorescent probe. It is possible that rare earth doped up-conversion nanomaterials have been widely used in fluorescence imaging. Because of the existence of a large number of unpaired 4f electrons, gadolinium modified nanoprobes and gadolinium based nanomaterials are commonly used in T_1 weighted magnetic resonance imaging. The rare earth elements have higher atomic numbers and stronger X ray attenuation coefficients than the iodine elements, and rare earth elements Kinami materials can be used in X ray and X ray tomography (CT) imaging. This paper will introduce the development and application of rare earth base multi mode nanoscale in recent years, and review its research progress in the field of biomedicine.

【作者单位】：稀土资源利用国家重点实验室/化学生物学实验室中国科学院长春应用化学研究所;
【基金】：国家自然科学基金(编号:21210002,21431007,21403209,21533008) 吉林省科技发展计划青年科研基金项目(编号:20160520129JH)资助
【分类号】：TQ421.7;TB383.1

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