镁合金表面药物释放功能膜层的制备与性能研究

发布时间：2018-05-27 21:16

本文选题：镁合金 + 生物材料　；参考：《西南大学》2017年硕士论文

【摘要】：由于在生物体内的可降解性能,镁合金在可降解生物材料领域受到越来越多的关注。其在生理介质环境中降解的主要产物为镁离子,这是一种人体必需元素,从而保证了良好的生物相容性。和传统的植入材料对比,镁合金植入材料在植入后期无需手术取出,这降低了病人身体和经济上的负担,同时也避免了不可降解材料在后期产生的炎症等问题。在力学性能方面,镁合金有着出色的密度小、比强度高比刚度高等优点,同时,优良的可加工性能保证了镁合金作为植入材料该有的力学支撑性能。和传统的植入材料相比,镁合金的力学强度与自然骨更为接近,从而避免了传统植入材料带来的应力屏蔽等负面影响。但是镁合金在植入材料的应用方向也存在着自身的缺陷-在生理介质中的快速腐蚀,在植入材料领域,通常还会涉及到感染、炎症以及血栓等问题,针对上述的问题,本文在镁合金表面制备了药物固载膜层的复合膜层,旨在解决快速腐蚀、感染、炎症、血栓等问题。(1)在过去的数十年里,骨科植入手术感染的发病率已经变得很低了,但是感染依旧是骨科植入手术中最严重的并发症之一,这将导致治疗周期的延长。植入材料表面抗生素药物固载是解决此类问题的最佳途径。本章节中设计了一种以AZ31镁合金为基体,通过微波水液法制备了羟基磷灰石(HA)为底层,通过浸泡法固载抗生素硫酸庆大霉素(GS),最后通过浸渍提拉聚己内酯(PCL)制备Mg/HAGS/PCL复合材料。微波水液法为GS的附着提供了较大的比表面积,PCL膜层的封闭作用为GS的缓慢释放提供了可能性,PCL表面的孔状结构形成了药物输送的通道,控制了GS的释放。电化学测试表明复合材料具有良好的耐蚀性能,在浸泡试验中控制镁离子的释放。(2)植入材料服役的时候会涉及到炎症的问题。因此文章设计了以镁合金为基体的药物固载的复合材料(Mg/Epoxy resin-ZnO/PCL-Ibuprofen),这种复合材料可以实现Mg2+和布洛芬的双相控制释放。复合膜层通过浸渍提拉法和喷涂法制备。复合膜层表面主要由纤维结构组成。致密的PE-ZnO膜层,充当物理阻拦层,抵制腐蚀介质对镁合金的腐蚀,提升了复合材料的耐蚀性能,同时也控制了镁离子释放。药物浸泡释放实验表明复合膜层能够提供约22天的药物释放性能。在这个阶段可以有效的解决因植入材料服役初期可能引起的炎症问题。同时,这种方法还可以应用到其他金属植入材料上。(3)生物可降解的药物洗脱血管支架的发展,主要是用来解决惰性金属材料支架引起的问题,主要有慢性炎症以及血栓形成等风险。镁合金药物溶出血管支架的研究就是生物可降解支架的一个研究方向。然而,镁合金在生理介质中的快速腐蚀抑制了镁合金的应用,另外,用来彻底解决血管疾病的多功能血管支架也需要更多的研究。基于以上问题,本实验体系设计了Mg/MgO/PLA-FA复合材料。即在AZ31镁合金基体上,通过在Hank’s溶液中阳极氧化制备氧化镁膜层,之后通过浸渍提拉法制备聚乳酸-阿魏酸膜层。电化学和浸泡实验结果表明密实的MgO/PLA-FA膜层能够为镁合金提供优异的耐蚀性能。药物浸泡溶出实验表明复合膜层能够提供约50天的药物释放功能。释放的阿魏酸能够降低血小板的粘附和聚集。另外,血液相容性测试表明复合材料有着很低的溶血率。这种复合材料为镁合金血管支架的发展提供了一种可行的方案。
[Abstract]:Magnesium alloys have attracted more and more attention in the field of biodegradable materials in the field of biodegradable biomaterials. The main product of their degradation in the physiological environment is magnesium ion, which is a necessary element of human body, thus ensuring good biocompatibility. Compared with traditional implants, magnesium alloy implants are implanted in the plant. There is no need for surgical removal in the late stage, which reduces the patient's physical and economic burden, but also avoids the problem of inflammation in the late stage. In mechanical properties, magnesium alloys have excellent density, higher strength than stiffness, and excellent processability, which guarantees the magnesium alloy as an implant. Compared with the traditional implants, the mechanical strength of the magnesium alloy is closer to the natural bone, thus avoiding the negative effects of the stress shielding of the traditional implants. However, the magnesium alloy has its own defect in the direction of the application of the implanted material - the rapid corrosion in the physiological medium and the implantation. In the field of materials, infection, inflammation, and thrombus are often involved. In this paper, the composite membrane of the drug immobilized membrane is prepared on the surface of magnesium alloy, aiming at solving the problems of rapid corrosion, infection, inflammation and thrombus. (1) in the past few decades, the incidence of surgical infection in the Department of orthopedics has become very low. But infection is still one of the most serious complications in the Department of orthopedics implantation, which will lead to the prolongation of the treatment cycle. The best way to solve such problems is the immobilization of antibiotics on the surface of the implant material. In this chapter, a AZ31 magnesium alloy is designed to prepare hydroxyapatite (HA) as the bottom layer by microwave water solution. The soaking method was used to immobilizing the antibiotic gentamicin sulfate (GS). Finally, the Mg/HAGS/PCL composite was prepared by impregnating the PCL. The microwave water liquid method provided a larger specific surface area for the attachment of GS. The sealing effect of the PCL film provided the possibility for the slow release of GS, and the pore structure of the PCL surface formed the channel of drug delivery. The release of GS was made. The electrochemical test showed that the composite had good corrosion resistance and controlled the release of magnesium ions in the immersion test. (2) the problem of inflammation was involved when the implant was served. Therefore, the composite material (Mg/Epoxy resin-ZnO/PCL-Ibuprofen), based on magnesium alloy as the matrix, was designed. The material can realize the dual phase control release of Mg2+ and Bloven. The composite film is prepared by impregnation drawing and spraying. The surface of the composite film is mainly composed of fiber structure. The dense PE-ZnO film acts as a physical barrier layer, resists corrosion of the corrosion medium to magnesium alloy, improves the corrosion resistance of the composite, and controls the magnesium separation. Drug release release. The drug soaking release experiment shows that the composite membrane can provide about 22 days of drug release performance. At this stage it can effectively solve the possible inflammatory problems caused by the early stage of the implant service. At the same time, this method can also be applied to other metal implant materials. (3) biodegradable drug eluting stent Development is mainly used to solve the problems caused by inert metal material stents, mainly including chronic inflammation and thrombosis. The study of magnesium alloy drug dissolving stent is a research direction of biodegradable scaffold. However, the rapid corrosion of magnesium alloys in physiological medium inhibits the application of magnesium alloys, in addition, it is used for magnesium alloy. More research is needed for the multifunctional vascular stent to solve vascular disease. Based on the above problems, the experimental system has designed Mg/MgO/PLA-FA composite. That is, on the matrix of AZ31 magnesium alloy, the Magnesium Oxide film is prepared by anodizing in Hank 's solution, and then the polylactic acid ferulic acid film is prepared by the impregnation and drawing method. The experimental results show that the dense MgO/PLA-FA film provides excellent corrosion resistance for magnesium alloy. The drug immersion dissolution test shows that the composite film provides about 50 days of drug release. The release of ferulic acid can reduce the adhesion and aggregation of platelets. In addition, the blood compatibility test shows that the composite is very low. This composite material provides a feasible solution for the development of magnesium alloy stent.
【学位授予单位】：西南大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：TB383.2;TQ460.1

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