羧甲基壳聚糖纳米胶束的制备与光响应性研究

发布时间：2018-05-28 16:21

本文选题：羧甲基壳聚糖 + 光响应　；参考：《华中师范大学学报(自然科学版)》2017年04期

【摘要】：智能响应性聚合物胶束作为药物控释传递系统的载体引起广泛关注,其中光刺激因为可控性高、清洁高效等优点被广泛研究.该文以丁二酸酐为连接臂将1-芘甲醇(PyM)接枝到羧甲基壳聚糖(CMCS)的氨基上制得两亲性大分子(PMS-g-CMCS),然后在水溶液中自组装成光响应纳米胶束.采用动态光散射(DLS)和透射电镜(TEM)表征胶束的大小和形态,并研究光刺激前后胶束的大小变化;通过核磁和荧光研究胶束的光响应机制.结果表明该胶束为类球形核-壳结构,粒径约200nm,且具有较好储存稳定性;在紫外(UV)光照下,能发生结构改变,其光响应机制可归因于连接PyM的酯键断裂.胶束显示出可用作疏水性药物或农药光控释放载体的潜力.
[Abstract]:Intelligent responsive polymer micelles have attracted much attention as carriers of drug delivery systems, among which photostimulation has been widely studied because of its high controllability, cleanliness and high efficiency. An amphiphilic macromolecule, PMS-g-CMCSN, was prepared by grafting 1-pyrene methanol-Pym onto the amino group of carboxymethyl chitosan (CMCSs) using succinic anhydride as the connecting arm, and then self-assembled in aqueous solution to form photo-responsive micelles. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) were used to characterize the size and morphology of micelles, and to study the changes of micelles size before and after photostimulation, and to study the photoresponse mechanism of micelles by NMR and fluorescence. The results show that the micelle is a spherical core-shell structure with a diameter of about 200 nm and a good storage stability. Under UV irradiation, the structure of the micelle can be changed, and the photoresponse mechanism can be attributed to the rupture of the ester bond attached to PyM. Micelles demonstrate the potential to be used as photo-controlled release carriers for hydrophobic drugs or pesticides.
【作者单位】：武汉理工大学化学化工与生命科学学院;
【基金】：国家自然科学基金项目(51373130) 武汉理工大学本科生创新研究基金(2016-HS-B1-12)
【分类号】：O636.1;TB383.1

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