新型纳米复合材料的无酶电化学传感研究

发布时间：2018-07-09 14:11

本文选题：无酶电化学传感器 + 电化学发光　；参考：《东北师范大学》2015年硕士论文

【摘要】：电化学传感器是目前生命科学及临床医学测试方法研究中最为活跃的领域之一,已广泛用于临床、工业、环境和农业分析等领域。纳米科学的出现、生长以及成熟,为电化学传感器的发展提供了很好的前提条件。最近几年,基于纳米材料比表面积大、表面反应活性高、电催化能力强等特性,越来越多的人们使用无酶电化学和电致发光技术,构建能够对双氧水,葡萄糖等物质进行检测的新型无酶电化学传感器。本论文基于纳米复合材料的优越性和电化学传感技术的灵敏性,构建了电化学性能优良的葡萄糖和过氧化氢新型电化学传感器,拓宽了电化学传感器的应用领域,具体内容如下:1.提出了一种基于钙钛矿型纳米复合材料(La Ti O3-Ag0.1)的新型无酶电化学发光葡萄糖传感器(La Ti O3-Ag0.1-modified-GCE)。用溶胶-凝胶的合成方法制备了La Ti O3-Ag0.1纳米复合材料,并采用一系列表征手段(SEM、TEM、XRD)和电化学测定方法对其形貌和电化学性能进行了研究。在最优化的实验条件下,测试了此传感器对葡萄糖检测的线性范围和检测限,并进一步研究了其实际应用性。2.研究了一种无酶电化学发光葡萄糖传感器(Au-HS/SO3H-PMO(Et)-modified GCE),这种能化纳米复合材料(Au-HS/SO3H-PMO(Et))以功能化有序介孔硅(HS/SO3H-PMO(Et))为载体,通过共价键作用将金纳米颗粒掺杂到有序介孔硅中。利用Au纳米颗粒好的电催化活性,实现了对葡萄糖的电催化氧化。3.研制出一种基于功能化纳米复合材料(Au-HS/SO3H-PMO(Et))的新型无酶过氧化氢传感器(Au-HS/SO3H-PMO(Et)-modified GCE),通过一系列的电化学测试手段,对修饰电极的电化学行为进行了考察,在最佳条件下,此传感器对过氧化氢的检测表现出了好的响应特性:高的灵敏度、低的检测限、宽的线性范围、好的选择性以及令人满意的实际应用性。4.构建了一种基于高醇羟基硝酸氧铋(HO-Bi ONO3)纳米复合材料的新型无酶葡萄糖传感器(HO-Bi ONO3-modified GCE)。应用一系列表征手段和电化学测试技术,对HO-Bi ONO3纳米复合材料的形貌、组成以及修饰电极对过氧化氢的检测进行了研究,并将其进一步应用于实际血样中葡萄糖的检测。
[Abstract]:Electrochemical sensor is one of the most active fields in the research of life science and clinical medicine testing methods. It has been widely used in the fields of clinical, industrial, environmental and agricultural analysis. The appearance, growth and maturity of nanoscience have provided a good premise for the development of electrochemical sensors. In recent years, the ratio of nano materials to nano materials is based on the ratio of nano materials. Large surface area, high surface reactivity, strong electrocatalysis ability and so on. More and more people use non enzyme electrochemistry and electroluminescent technology to construct a new non enzyme electrochemical sensor which can detect hydrogen peroxide and glucose. This paper is based on the advantages of nanocomposites and the sensitivity of electrochemical sensing technology. A new electrochemical biosensor with excellent electrochemical performance for glucose and hydrogen peroxide has been constructed, which widens the application field of electrochemical sensors. The specific contents are as follows: 1. a novel non enzyme electrochemiluminescence glucose sensor (La Ti O3-Ag0.1-modified-GCE) based on the perovskite nano composite material (La Ti O3-Ag0.1) is proposed. La Ti O3-Ag0.1 nanocomposites were prepared by the synthetic method of gel gel. The morphology and electrochemical properties of the nanocomposites were studied by a series of characterization methods (SEM, TEM, XRD) and electrochemical methods. The linear range and detection limit of the sensor on the detection of grape sugar were tested under the optimal experimental conditions. Its practical application.2. has studied an enzyme free electrochemiluminescence glucose sensor (Au-HS/SO3H-PMO (Et) -modified GCE). This energetic nanocomposite (Au-HS/SO3H-PMO (Et)) is supported by functional ordered mesoporous Kong Gui (Et). Gold nanoparticles are doped into the ordered mesoporous silica through the covalent bond, and Au nanoscale is used. A new type of non enzyme hydrogen peroxide sensor (Au-HS/SO3H-PMO (Et) -modified GCE) based on functionalized nano composite material (Au-HS/SO3H-PMO (Et)) was developed for the electrocatalytic oxidation of glucose. The electrochemical behavior of the modified electrode was investigated by a series of electrochemical testing methods, and the electrochemical behavior of the modified electrode was investigated. The electrochemical behavior of the modified electrode was investigated by a series of electrochemical testing methods. Under optimal conditions, the sensor has good response characteristics to the detection of hydrogen peroxide: high sensitivity, low detection limit, wide linear range, good selectivity and satisfactory practical application.4., a novel enzyme free glucose sensor based on HO-Bi ONO3 nanocomposite (HO) nanocomposite (HO) is constructed. -Bi ONO3-modified GCE). Using a series of characterization methods and electrochemical testing techniques, the morphology and composition of HO-Bi ONO3 nanocomposites and the detection of hydrogen peroxide by modified electrode were studied, and it was further applied to the detection of glucose in the actual blood samples.
【学位授予单位】：东北师范大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：TB33;O657.1

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