球状单分散介孔二氧化硅MCM-41纳米颗粒的合成
发布时间：2018-08-16 08:42
【摘要】：介孔材料自发现以来，凭借自身的一些优异的特征，例如大的比表面积、可调变的介孔孔径、表面可通过各种修饰实现“官能化”等，在催化、分离、药物与生物活性分子的负载等许多领域有广泛的应用前景。随着纳米制备技术的发展，介孔纳米颗粒在基因载体和药物载体方面，发现越来愈多的应用前景。介孔二氧化硅纳米颗粒作为理想基因和药物载体，对其颗粒的尺寸、形貌、分散性等的参数的要求便至关重要。因此，探讨球状单分散的介孔二氧化硅MCM-41纳米颗粒的合成的方法便具有理论与现实的意义。 本文使用了两种方法制备了球状单分散介孔二氧化硅MCM-41纳米颗粒，并探讨了合成因素的影响。一是添加剂法，即在尿素合成体系中，加入合适的添加剂，利用其某些特定作用包括抑制、分散、封装等去改善介孔二氧化硅纳米颗粒的质量、大小以及均一性等；二是缓冲剂法，利用Tris-HCl缓冲溶液消除pH值不稳定带来的纳米颗粒不均相增长，制备出单分散形貌均一的二氧化硅纳米颗粒。然后，改变温度和体系的pH值合成一系列的介孔二氧化硅纳米颗粒。 在添加剂法中，通过SEM、TEM、XRD、热重分析等测试手段表明：添加剂的加入使尿素的使用量的大大降低，，从9.300g降低到了3.096g；在乙醇胺、酒石酸和丙三醇的帮助下，合成的介孔二氧化硅纳米颗粒具有较好的XRD衍射峰，高的单分散性和大小均一的球形形貌，颗粒的尺寸可以被调制在75nm到200nm。与没有添加剂相比，在颗粒的形貌与单分散性保证的前提下，颗粒尺寸下降了一个数量级。 在Tris-HCl缓冲体系中，能够得到非常完美的介孔二氧化硅纳米颗粒。结果表明：当体系反应温度为60℃，pH值在7.8～8.2范围内，反应时间为16h，为合成理想的、单分散、球形均一的介孔的材料的最佳反应条件。此外，通过改变温度以及合成pH值，可以制备出尺寸在80～300nm可调，分散性高的、形貌均一的、有序的介孔MCM-41纳米颗粒，为其应用成为理想的基因载体和药物载体做了良好的铺垫。
[Abstract]:Since its discovery, mesoporous materials have been catalyzed and separated by their own excellent characteristics, such as large specific surface area, adjustable mesoporous pore size, and "functionalization" of the surface through various modifications. Many fields, such as drug and bioactive molecule loading, have a wide application prospect. With the development of nanometer preparation technology, more and more applications of mesoporous nanoparticles have been found in gene carriers and drug carriers. As an ideal gene and drug carrier, mesoporous silica nanoparticles are very important for their particle size, morphology and dispersity. Therefore, it is of theoretical and practical significance to study the synthesis of spherical monodisperse mesoporous silica MCM-41 nanoparticles. In this paper, the spherical monodisperse mesoporous silica MCM-41 nanoparticles were prepared by two methods, and the effects of synthesis factors were discussed. One is additive method, that is, adding suitable additive in urea synthesis system, using some specific functions, such as inhibition, dispersion, encapsulation and so on, to improve the quality, size and uniformity of mesoporous silica nanoparticles. Secondly, the Tris-HCl buffer solution was used to eliminate the uneven phase growth of nano-particles caused by the instability of pH value, and the monodisperse silica nanoparticles were prepared. Then, a series of mesoporous silica nanoparticles were synthesized by changing the temperature and pH value of the system. In the additive method, the addition of the additive reduced the usage of urea from 9.300 g to 3.096 g, with the help of ethanolamine, tartaric acid and glycerol. The synthesized mesoporous silica nanoparticles have good XRD diffraction peak, high monodispersity and uniform spherical morphology. The size of the particles can be modulated from 75nm to 200nm. Compared with no additives, the particle size decreased by one order of magnitude under the guarantee of the morphology and monodispersity of the particles. Perfect mesoporous silica nanoparticles can be obtained in Tris-HCl buffer system. The results show that when the reaction temperature is 60 鈩
本文编号：2185476
[Abstract]:Since its discovery, mesoporous materials have been catalyzed and separated by their own excellent characteristics, such as large specific surface area, adjustable mesoporous pore size, and "functionalization" of the surface through various modifications. Many fields, such as drug and bioactive molecule loading, have a wide application prospect. With the development of nanometer preparation technology, more and more applications of mesoporous nanoparticles have been found in gene carriers and drug carriers. As an ideal gene and drug carrier, mesoporous silica nanoparticles are very important for their particle size, morphology and dispersity. Therefore, it is of theoretical and practical significance to study the synthesis of spherical monodisperse mesoporous silica MCM-41 nanoparticles. In this paper, the spherical monodisperse mesoporous silica MCM-41 nanoparticles were prepared by two methods, and the effects of synthesis factors were discussed. One is additive method, that is, adding suitable additive in urea synthesis system, using some specific functions, such as inhibition, dispersion, encapsulation and so on, to improve the quality, size and uniformity of mesoporous silica nanoparticles. Secondly, the Tris-HCl buffer solution was used to eliminate the uneven phase growth of nano-particles caused by the instability of pH value, and the monodisperse silica nanoparticles were prepared. Then, a series of mesoporous silica nanoparticles were synthesized by changing the temperature and pH value of the system. In the additive method, the addition of the additive reduced the usage of urea from 9.300 g to 3.096 g, with the help of ethanolamine, tartaric acid and glycerol. The synthesized mesoporous silica nanoparticles have good XRD diffraction peak, high monodispersity and uniform spherical morphology. The size of the particles can be modulated from 75nm to 200nm. Compared with no additives, the particle size decreased by one order of magnitude under the guarantee of the morphology and monodispersity of the particles. Perfect mesoporous silica nanoparticles can be obtained in Tris-HCl buffer system. The results show that when the reaction temperature is 60 鈩
本文编号：2185476
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