单个体矢量性特征的固体纳米孔道分析研究
发布时间：2018-12-08 20:36
【摘要】：固体纳米孔道作为一种高灵敏的单分子检测技术,由于其机械强度高、尺寸可控、易于阵列化集成等方面的显著优势,已经被广泛应用于DNA,蛋白质以及聚合物等小分子的检测.具有矢量性特征的各向异性单个体在纳米孔道中的穿孔行为对具有空间限域效应的纳米孔道离子流特征信号具有显著影响.为解析单个体矢量性特征对纳米孔道分析的影响,本工作利用氮化硅固态纳米孔道,以单个纳米金棒为各向异性的单个体模型,实时观测了其在孔道中的迁移行为.研究发现当纳米金棒穿过纳米孔道时,产生两种不同阻断程度的特征电流信号,通过对电流信号事件的解析,实时获取了具有矢量特征的金棒所导致的两种特征过孔事件;进一步,建立了离子电流模型,分别对这两种各向异性的穿孔事件机制进行了验证.
[Abstract]:As a highly sensitive single molecule detection technique, solid nano-channel has been widely used in DNA, because of its advantages of high mechanical strength, controllable size and easy to be integrated into array. Detection of small molecules such as proteins and polymers. The perforation behavior of an anisotropic single individual with vector characteristics in the nanopore has a significant effect on the characteristic signal of the nanorph ion current with the spatial limiting effect. In order to analyze the effect of single individual vector characteristics on the analysis of nano-pore, the migration behavior of silicon nitride solid nano-channel was observed in real time by using a single individual model with a single nanorod as anisotropy. It is found that two kinds of characteristic current signals with different blocking degree are produced when the nanocrystalline gold rods pass through the nanorods. By analyzing the current signal events, two kinds of characteristic perforation events caused by the gold rods with vector characteristics are obtained in real time. Furthermore, ion current models are established to verify the two anisotropic perforation event mechanisms.
【作者单位】： 华东理工大学化学与分子工程学院结构可控先进功能材料及其制备教育部重点实验室;华东理工大学信息科学与工程学院;
【基金】：国家自然科学基金(Nos.21505043,21421004,21327807) 中央高校基本科研业务费(Nos.222201718001,222201717003,222201714012)资助~~
【分类号】：TB383.1
本文编号：2368965
[Abstract]:As a highly sensitive single molecule detection technique, solid nano-channel has been widely used in DNA, because of its advantages of high mechanical strength, controllable size and easy to be integrated into array. Detection of small molecules such as proteins and polymers. The perforation behavior of an anisotropic single individual with vector characteristics in the nanopore has a significant effect on the characteristic signal of the nanorph ion current with the spatial limiting effect. In order to analyze the effect of single individual vector characteristics on the analysis of nano-pore, the migration behavior of silicon nitride solid nano-channel was observed in real time by using a single individual model with a single nanorod as anisotropy. It is found that two kinds of characteristic current signals with different blocking degree are produced when the nanocrystalline gold rods pass through the nanorods. By analyzing the current signal events, two kinds of characteristic perforation events caused by the gold rods with vector characteristics are obtained in real time. Furthermore, ion current models are established to verify the two anisotropic perforation event mechanisms.
【作者单位】： 华东理工大学化学与分子工程学院结构可控先进功能材料及其制备教育部重点实验室;华东理工大学信息科学与工程学院;
【基金】：国家自然科学基金(Nos.21505043,21421004,21327807) 中央高校基本科研业务费(Nos.222201718001,222201717003,222201714012)资助~~
【分类号】：TB383.1
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