β-TCP基复合材料的制备及降解性能的研究
发布时间：2018-12-30 11:52
【摘要】：优异的生物相容性、骨引导及骨诱导性,这些独特的性质使β-TCP成为一种很有前景的骨修复材料。但其在中性或碱性环境中比较稳定,降解过于缓慢。研究表明,磷酸镁、UPPE等高分子材料降解较快,与β-TCP复合形成降解性能优异的复合材料。因此本文系统研究了β-TCP及其复合材料的制备及降解性能。采用沉淀法和水热法制备了β-TCP粉体,并对其进行一系列的基础表征测试。在沉淀法的制备过程中,发现当Ca/P比约为1.5,煅烧温度高于800℃时,可得到较纯净的β-TCP。此外,煅烧温度会影响粉体的颗粒尺寸:煅烧温度越低,得到的粉体的颗粒尺寸越小。水热法的制备、表征结果发现,水热法并不适合制备单相的β-TCP粉体,比较适合制备β-TCP/HA双相陶瓷粉末;提高水热温度和延长水热时间均能提高β-TCP/HA复合材料中HA的含量。采用化学共沉淀法制备了Ca/Mg/PO4复合粉体,发现复合材料主要由β-TCP和Ca4Mg5(PO4)6两相组成,Mg用量越多,第二相Ca4Mg5(PO4)6的含量越高。采用凝胶注模成型法制备了β-TCP/UPPE复合材料,发现UPPE含量越多,UPPE对β-TCP的包覆作用越强。将β-TCP、Ca/Mg/PO4复合材料、β-TCP/UPPE复合材料在模拟体液中进行降解实验。发现单相的β-TCP材料降解较慢,材料表面颗粒尺寸不断减小,但材料质量不断增大。其降解机理为:β-TCP溶出钙磷离子,钙磷离子以HA、β-Ca3(PO4)2的形式析出,整个过程析出速率大于溶出速率。发现Ca/Mg/PO4复合材料降解较快,30天后其质量损失约为2%,其中,Ca4Mg5(PO4)6溶解速度较快,因而使得钙磷离子的溶出速率加快。发现β-TCP/UPPE复合材料降解速率显著提高,30天内质量损失达到15%~35%。其降解机理为:UPPE降解较快,降解后产生的酸性物质使溶液pH降低,从而促进了β-TCP的降解,使得钙磷离子的释放加快,因而钙磷离子的溶出速度远远快于析出速度。三种材料在降解过程中相组成均比较稳定,材料表面出现HA的少量沉积,HA会阻碍材料的进一步降解,但阻碍作用并不大。
[Abstract]:Excellent biocompatibility, bone guidance and bone induction make 尾-TCP a promising bone repair material. However, it is stable in neutral or alkaline environment, and its degradation is too slow. The results showed that the polymer materials such as magnesium phosphate and UPPE degraded rapidly and formed a composite with 尾-TCP with excellent degradability. Therefore, the preparation and degradation properties of 尾-TCP and its composites were systematically studied in this paper. 尾-TCP powders were prepared by precipitation method and hydrothermal method. In the preparation process of precipitation method, when the Ca/P ratio is about 1.5 and the calcination temperature is higher than 800 鈩，
本文编号：2395544
[Abstract]:Excellent biocompatibility, bone guidance and bone induction make 尾-TCP a promising bone repair material. However, it is stable in neutral or alkaline environment, and its degradation is too slow. The results showed that the polymer materials such as magnesium phosphate and UPPE degraded rapidly and formed a composite with 尾-TCP with excellent degradability. Therefore, the preparation and degradation properties of 尾-TCP and its composites were systematically studied in this paper. 尾-TCP powders were prepared by precipitation method and hydrothermal method. In the preparation process of precipitation method, when the Ca/P ratio is about 1.5 and the calcination temperature is higher than 800 鈩，
本文编号：2395544
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